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Dimethyltubocurarine chloride

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Chemical compound
Pharmaceutical compound
Dimethyltubocurarine chloride
Clinical data
Other names(+)-O,O'-dimethyl-tubocurine dichloride
ATC code
Identifiers
  • (1S,16R)-9,10,21,25-Tetramethoxy-15,15,30,30-tetramethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaene-15,30-diium dichloride
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.046.768 Edit this at Wikidata
Chemical and physical data
Formula C40H48Cl2N2O6
Molar mass 723.73 g·mol−1
3D model (JSmol)
    • C[N+]1(CCc2cc(c3cc2[C@@H]1Cc4ccc(cc4)Oc5c6c(cc(c5OC)OC)CC[N+]([C@@H]6Cc7ccc(c(c7)O3)OC)(C)C)OC)C.[Cl-].[Cl-]
    • InChI=1S/C40H48N2O6.2ClH/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-40-38-28(23-37(45-7)39(40)46-8)16-18-42(3,4)32(38)20-26-11-14-33(43-5)35(21-26)48-36;;/h9-14,21-24,31-32H,15-20H2,1-8H3;2*1H/q+2;;/p-2/t31-,32+;;/m0../s1
    • Key:IRPSJVWFSWAZSZ-OIUSMDOTSA-L
     ☒NcheckY (what is this?)   (verify)

    Dimethyltubocurarine chloride (INN; also known as metocurine chloride (USAN) is a non-depolarizing nicotinic acetylcholine receptor antagonist used as a muscle relaxant.[1] [2]

    References

    [edit ]
    1. ^ United States Public Health Service (1965). Public Health Service Publication. U.S. Department of Health, Education, and Welfare, Public Health Service, Environmental Health Service, National Air Pollution Control Administration. p. 126.
    2. ^ Savarese JJ, Ali HH, Antonio RP (September 1977). "The clinical pharmacology of metocurine: dimethyltubocurarine revisited". Anesthesiology. 47 (3): 277–84. doi:10.1097/00000542-197709000-00009. PMID 70179.
    Peripherally acting
    (primarily antinicotinic,
    NMJ block)
    Non-depolarizing
    Curare alkaloids
    4° ammonium agents
    Depolarizing
    ACh release inhibitors
    Centrally acting
    Carbamic acid esters
    Benzodiazepines
    Nonbenzodiazepines
    Thienodiazepines
    Quinazolines
    Anticholinergics
    (Antimuscarinics)
    Other
    Directly acting
    nAChRs Tooltip Nicotinic acetylcholine receptors
    Agonists
    (and PAMs Tooltip positive allosteric modulators)
    Antagonists
    (and NAMs Tooltip negative allosteric modulators)
    Precursors
    (and prodrugs)
    Stub icon

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