Calmodulin-regulated spectrin-associated protein 3
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Microtubule minus-end binding human protein
Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred to as Nezha.
Function
[edit ]CAMSAP3 acts as a minus-end anchor of microtubules, and binds to them through its CKK domain.[5]
In epithelial cells, it anchors microtubules to the apical cortex, causing them to grow in an apical-to-basal direction.[6] This gives the epithelial cells their rectangular shape.
In other species
[edit ]In early mouse embryogenesis, the interphase bridge linking sister cells is enriched with CAMSAP3.[7]
See also
[edit ]References
[edit ]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000076826 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044433 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Baines, A. J.; Bignone, P. A.; King, M. D.A.; Maggs, A. M.; Bennett, P. M.; Pinder, J. C.; Phillips, G. W. (2009年09月01日). "The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins". Molecular Biology and Evolution. 26 (9): 2005–2014. doi:10.1093/molbev/msp115 . ISSN 0737-4038. PMID 19508979. Archived from the original on 2022年06月15日. Retrieved 2022年09月29日.
- ↑ Toya M, Kobayashi S, Kawasaki M, Shioi G, Kaneko M, Ishiuchi T, et al. (January 2016). "CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 113 (2): 332–337. Bibcode:2016PNAS..113..332T. doi:10.1073/pnas.1520638113 . PMC 4720291 . PMID 26715742.
- ↑ Zenker J, White MD, Templin RM, Parton RG, Thorn-Seshold O, Bissiere S, Plachta N (September 2017). "A microtubule-organizing center directing intracellular transport in the early mouse embryo". Science. 357 (6354): 925–928. Bibcode:2017Sci...357..925Z. doi:10.1126/science.aam9335 . PMID 28860385. S2CID 206658036.