Mitochondrial pyruvate carrier 2

Mitochondrial pyruvate carrier 2 (MPC2) also known as brain protein 44 (BRP44) is a protein that in humans is encoded by the MPC2 gene.^{[5] [6] [7]} It is a member of the Mitochondrial Pyruvate Carrier (MPC) protein family.^[8] This protein is involved in transport of pyruvate across the inner membrane of mitochondria in preparation for the pyruvate dehydrogenase reaction.^[9]

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

Mutations in the MPC2 gene cause an autosomal recessive disease comparable to the symptoms of Mitochondrial pyruvate carrier deficiency (MPC1 gene).^[10] The symptoms associated with mutations in the MPC2 gene include early-onset neurological problems, normal lactate/pyruvate ratio (however both lactate and pyruvate are in higher than normal concentrations), lactic acidosis, hypotonia, cardiomegaly, and facial dysmorphia.^[10]

• Mitochondrial pyruvate carrier 1 (MPC1)
• Inborn errors of carbohydrate metabolism

• Genes on human chromosome 1
• Human chromosome 1 gene stubs
• Inborn errors of carbohydrate metabolism
• Autosomal recessive disorders
• Transport proteins
• Solute carrier family

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