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BRAT1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
BRAT1
Available structures
PDB Ortholog search: PDBe RCSB
List of PDB id codes

4IFI

Identifiers
Aliases BRAT1 , BAAT1, C7orf27, RMFSL, BRCA1 associated ATM activator 1, NEDCAS
External IDsOMIM: 614506; MGI: 1891679; HomoloGene: 16776; GeneCards: BRAT1; OMA:BRAT1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human) [1]
Band 7p22.3Start2,537,810 bp [1]
End2,555,694 bp [1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr. Chromosome 5 (mouse)[2]
Band 5|5 G2Start140,690,766 bp [2]
End140,705,134 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
Top expressed in
  • left adrenal cortex

  • granulocyte

  • right adrenal gland

  • right adrenal cortex

  • right testis

  • left testis

  • gonad

  • right hemisphere of cerebellum

  • right uterine tube

  • right ovary
Top expressed in
  • interventricular septum

  • granulocyte

  • Rostral migratory stream

  • spermatocyte

  • lumbar spinal ganglion

  • right kidney

  • ascending aorta

  • endocardial cushion

  • external carotid artery

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

221927

231841

Ensembl

ENSG00000106009

ENSMUSG00000000148

UniProt

Q6PJG6

Q8C3R1

RefSeq (mRNA)

NM_152743
NM_001350626
NM_001350627

NM_001276287
NM_172724
NM_181066

RefSeq (protein)

NP_689956
NP_001337555
NP_001337556

NP_001263216
NP_851411

Location (UCSC)Chr 7: 2.54 – 2.56 Mb Chr 5: 140.69 – 140.71 Mb
PubMed search[3] [4]
Wikidata
View/Edit Human View/Edit Mouse

BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene.[5]

Function

[edit ]

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.[5]

References

[edit ]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106009 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000148 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: BRCA1-associated ATM activator 1".
[edit ]
  • Human BRAT1 genome location and BRAT1 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human BRCA1-associated ATM activator
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