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BAAT

From Wikipedia, the free encyclopedia

Mammalian protein found in Homo sapiens

BAAT

Identifiers

BAAT , BACAT, BAT, bile acid-CoA:amino acid N-acyltransferase, BACD1, HCHO

External IDs

OMIM: 602938; MGI: 106642; HomoloGene: 1286; GeneCards: BAAT; OMA:BAAT - orthologs

Gene location (Human)
Chromosome 9 (human)
Chr.	Chromosome 9 (human) ^[1]
Chromosome 9 (human) Genomic location for BAAT Genomic location for BAAT
Band	9q31.1	Start	101,354,182 bp ^[1]
Band	9q31.1	End	101,385,400 bp ^[1]

Gene location (Mouse)
Chromosome 4 (mouse)
Chr.	Chromosome 4 (mouse)^[2]
Chromosome 4 (mouse) Genomic location for BAAT Genomic location for BAAT
Band	4 B1\|4 26.51 cM	Start	49,489,422 bp ^[2]
Band	4 B1\|4 26.51 cM	End	49,506,557 bp ^[2]

RNA expression pattern

Human	Mouse (ortholog)
Top expressed in liver right lobe of liver gallbladder islet of Langerhans superior frontal gyrus primary visual cortex gastrocnemius muscle Brodmann area 9 muscle of thigh prefrontal cortex	Top expressed in left lobe of liver gallbladder embryo embryo Ileal epithelium lactiferous gland right kidney jejunum thoracic diaphragm yolk sac
More reference expression data

More reference expression data

Gene ontology
Molecular function	thiolester hydrolase activity very long chain acyl-CoA hydrolase activity signaling receptor binding transferase activity medium-chain acyl-CoA hydrolase activity hydrolase activity N-acyltransferase activity palmitoyl-CoA hydrolase activity long-chain acyl-CoA hydrolase activity carboxylic ester hydrolase activity glycine N-choloyltransferase activity protein binding acyltransferase activity myristoyl-CoA hydrolase activity acyl-CoA hydrolase activity
Cellular component	cytoplasm peroxisome peroxisomal matrix cytosol
Biological process	bile acid conjugation liver development lipid metabolism animal organ regeneration acyl-CoA metabolic process taurine metabolic process bile acid metabolic process glycine metabolic process bile acid biosynthetic process fatty acid metabolic process protein targeting to peroxisome
Sources:Amigo / QuickGO

Species

Human

Mouse


570


12012


ENSG00000136881 ENSG00000276559


ENSMUSG00000039653


Q14032


Q91X34

RefSeq (mRNA)

NM_001701
NM_001127610
NM_001374715

RefSeq (protein)

NP_001121082
NP_001692
NP_001361644

Location (UCSC)

Chr 9: 101.35 – 101.39 Mb

Chr 4: 49.49 – 49.51 Mb

PubMed search

^[3]

^[4]

View/Edit Human View/Edit Mouse

Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene.^[5]

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract.^[5]

References

^ ^a ^b ^c ENSG00000276559 GRCh38: Ensembl release 89: ENSG00000136881, ENSG00000276559 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039653 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)".

External links

Human BAAT genome location and BAAT gene details page in the UCSC Genome Browser.

Further reading

Johnson MR, Barnes S, Kwakye JB, Diasio RB (1991). "Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver". J. Biol. Chem. 266 (16): 10227–33. doi:10.1016/S0021-9258(18)99213-6 . PMID 2037576.
Falany CN, Johnson MR, Barnes S, Diasio RB (1994). "Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase". J. Biol. Chem. 269 (30): 19375–9. doi:10.1016/S0021-9258(17)32178-6 . PMID 8034703.
Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics. 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
Solaas K, Ulvestad A, Söreide O, Kase BF (2000). "Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts". J. Lipid Res. 41 (7): 1154–62. doi:10.1016/S0022-2275(20)32022-8 . PMID 10884298.
Sfakianos MK, Wilson L, Sakalian M, et al. (2003). "Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase". J. Biol. Chem. 277 (49): 47270–5. doi:10.1074/jbc.M207463200 . PMID 12239217.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Carlton VE, Harris BZ, Puffenberger EG, et al. (2003). "Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT". Nat. Genet. 34 (1): 91–6. doi:10.1038/ng1147. PMID 12704386. S2CID 21900697.
Wang H, Tamba M, Kimata M, et al. (2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT". Biochem. Biophys. Res. Commun. 305 (3): 611–8. doi:10.1016/S0006-291X(03)00808-8. PMID 12763038.
O'Byrne J, Hunt MC, Rai DK, et al. (2003). "The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine". J. Biol. Chem. 278 (36): 34237–44. doi:10.1074/jbc.M300987200 . PMID 12810727.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Pellicoro A, van den Heuvel FA, Geuken M, et al. (2007). "Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport". Hepatology. 45 (2): 340–8. doi:10.1002/hep.21528 . PMID 17256745. S2CID 6163420.
Tougou K, Fukuda T, Ito T, et al. (2007). "Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals". Drug Metab. Pharmacokinet. 22 (2): 125–8. doi:10.2133/dmpk.22.125 . PMID 17495420.

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