ATP6V0D2

Protein-coding gene in the species Homo sapiens

ATP6V0D2

Identifiers

ATP6V0D2 , ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2, ATP6D2, VMA6, ATPase H+ transporting V0 subunit d2

External IDs

OMIM: 618072; MGI: 1924415; HomoloGene: 72090; GeneCards: ATP6V0D2; OMA:ATP6V0D2 - orthologs

Gene location (Human)
Chromosome 8 (human)
Chr.	Chromosome 8 (human) ^[1]
Chromosome 8 (human) Genomic location for ATP6V0D2 Genomic location for ATP6V0D2
Band	8q21.3	Start	85,987,323 bp ^[1]
Band	8q21.3	End	86,154,225 bp ^[1]

Gene location (Mouse)
Chromosome 4 (mouse)
Chr.	Chromosome 4 (mouse)^[2]
Chromosome 4 (mouse) Genomic location for ATP6V0D2 Genomic location for ATP6V0D2
Band	4\|4 A3	Start	19,876,841 bp ^[2]
Band	4\|4 A3	End	19,922,605 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in human kidney buccal mucosa cell amniotic fluid renal medulla testicle rectum tibia muscle of thigh mucosa of transverse colon skin of hip	Top expressed in lumbar spinal ganglion submandibular gland body of femur parotid gland decidua right kidney calvaria human kidney right lung right lung lobe
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding proton transmembrane transporter activity P-type proton-exporting transporter activity proton-transporting ATPase activity, rotational mechanism
Cellular component	proton-transporting V-type ATPase, V0 domain endosome phagocytic vesicle membrane membrane apical plasma membrane vacuolar proton-transporting V-type ATPase complex endosome membrane extracellular exosome lysosomal membrane early endosome plasma membrane proton-transporting V-type ATPase complex
Biological process	insulin receptor signaling pathway transferrin transport ion transport ion transmembrane transport regulation of macroautophagy phagosome acidification vacuolar transport vacuolar acidification transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


245972


242341

Ensembl


ENSG00000147614


ENSMUSG00000028238

UniProt


Q8N8Y2


Q80SY3

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8: 85.99 – 86.15 Mb

Chr 4: 19.88 – 19.92 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 is a protein in humans that is encoded by the ATP6V0D2 gene. ^[5] It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption. ^[6]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147614 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028238 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2" . Retrieved 2012年11月12日.
^ Wu H, Xu G, Li YP (May 2009). "Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption". Journal of Bone and Mineral Research. 24 (5): 871–85. doi:10.1359/jbmr.081239. PMC 2672205 . PMID 19113919.

External links

[edit ]

Human ATP6V0D2 genome location and ATP6V0D2 gene details page in the UCSC Genome Browser.

References

External links

Further reading