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AP1AR

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

AP1AR

Identifiers

AP1AR , 2C18, C4orf16, GBAR, gamma-BAR, PRO0971, adaptor related protein complex 1 associated regulatory protein

External IDs

OMIM: 610851; MGI: 2384822; HomoloGene: 10236; GeneCards: AP1AR; OMA:AP1AR - orthologs

Gene location (Human)
Chromosome 4 (human)
Chr.	Chromosome 4 (human) ^[1]
Chromosome 4 (human) Genomic location for AP1AR Genomic location for AP1AR
Band	4q25	Start	112,231,740 bp ^[1]
Band	4q25	End	112,273,110 bp ^[1]

Gene location (Mouse)
Chromosome 3 (mouse)
Chr.	Chromosome 3 (mouse)^[2]
Chromosome 3 (mouse) Genomic location for AP1AR Genomic location for AP1AR
Band	3\|3 G2	Start	127,600,656 bp ^[2]
Band	3\|3 G2	End	127,631,172 bp ^[2]

RNA expression pattern

Human	Mouse (ortholog)
Top expressed in Achilles tendon ganglionic eminence jejunal mucosa rectum monocyte testicle ventricular zone mucosa of sigmoid colon stromal cell of endometrium islet of Langerhans	Top expressed in trigeminal ganglion epithelium of small intestine conjunctival fornix vestibular membrane of cochlear duct dorsal striatum Ileal epithelium primitive streak corneal stroma entorhinal cortex vestibular sensory epithelium
More reference expression data

More reference expression data

Gene ontology
Molecular function	kinesin binding AP-1 adaptor complex binding
Cellular component	late endosome Golgi apparatus early endosome transport vesicle cytosol endosome
Biological process	protein transport negative regulation of cell motility negative regulation of substrate adhesion-dependent cell spreading regulation of Arp2/3 complex-mediated actin nucleation negative regulation of receptor recycling vesicle targeting, trans-Golgi to endosome
Sources:Amigo / QuickGO

Species

Human

Mouse


55435


211556


ENSG00000138660


ENSMUSG00000074238


Q63HQ0


n/a

RefSeq (mRNA)

NM_001128426
NM_018569

NM_145964
NM_001346718

RefSeq (protein)

NP_001121898
NP_061039

n/a

Location (UCSC)

Chr 4: 112.23 – 112.27 Mb

Chr 3: 127.6 – 127.63 Mb

PubMed search

^[3]

^[4]

View/Edit Human View/Edit Mouse

AP-1 complex-associated regulatory protein (Gamma1-adaptin brefeldin A resistance protein) is a protein that in humans is encoded by the AP1AR gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138660 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074238 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neubrand VE, Will RD, Mobius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson JC (Apr 2005). "Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking". EMBO J. 24 (6): 1122–33. doi:10.1038/sj.emboj.7600600. PMC 556403 . PMID 15775984.
^ "Entrez Gene: C4orf16 chromosome 4 open reading frame 16".

External links

Human AP1AR genome location and AP1AR gene details page in the UCSC Genome Browser.

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466 . PMID 15815621.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.

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