ANXA8L1

Protein

ANXA8L1

Identifiers

Aliases

ANXA8L1 , ANXA8L2, VAC-beta, bA145E20.2, annexin A8-like 1, annexin A8 like 1

External IDs

MGI: 1201374; GeneCards: ANXA8L1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1W3W

Gene location (Human)
Chromosome 10 (human)
Chr.	Chromosome 10 (human) ^[1]
Chromosome 10 (human) Genomic location for ANXA8L1 Genomic location for ANXA8L1
Band	10q11.22	Start	46,375,627 bp ^[1]
Band	10q11.22	End	46,391,784 bp ^[1]

Gene location (Mouse)
Chromosome 14 (mouse)
Chr.	Chromosome 14 (mouse)^[2]
Chromosome 14 (mouse) Genomic location for ANXA8L1 Genomic location for ANXA8L1
Band	14 B\|14 20.8 cM	Start	33,807,938 bp ^[2]
Band	14 B\|14 20.8 cM	End	33,822,528 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in skin of abdomen skin of leg mucosa of esophagus placenta right lung vagina olfactory zone of nasal mucosa upper lobe of left lung minor salivary glands testicle	Top expressed in skin of external ear corneal stroma lip conjunctival fornix ankle ankle joint skin of back skin of abdomen decidua esophagus
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calcium-dependent phospholipid binding metal ion binding calcium ion binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding actin filament binding
Cellular component	extracellular exosome intracellular anatomical structure
Biological process	endosome organization endosomal transport negative regulation of serine-type endopeptidase activity negative regulation of phospholipase A2 activity
Sources:Amigo / QuickGO

Orthologs

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse

Entrez


728113


11752

Ensembl


ENSG00000264230


ENSMUSG00000021950

UniProt


Q5VT79


O35640

RefSeq (mRNA)

NM_001039801
NM_001098845
NM_001278923
NM_001278924
NM_001630

NM_001281845
NM_013473

RefSeq (protein)

NP_001092315
NP_001265852
NP_001265853

NP_001268774
NP_038501

Location (UCSC)

Chr 10: 46.38 – 46.39 Mb

Chr 14: 33.81 – 33.82 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Annexin A8-like protein 1 is a protein that in humans is encoded by the ANXA8L1 gene (previously ANXA8L2).^[5]

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.^[5]

References

[edit ]

1 2 3 GRCh38: Ensembl release 89: ENSG00000264230 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021950 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "ANXA8L1 annexin A8 like 1 [ Homo sapiens (human) ]" . Retrieved 2026年08月10日.

External links

[edit ]

Human ANXA8L1 genome location and ANXA8L1 gene details page in the UCSC Genome Browser .

Gerke V, Moss SE (2002). "Annexins: from structure to function". Physiol. Rev. 82 (2): 331–71. doi:10.1152/physrev.00030.2001. PMID 11917092.
Gerke V, Creutz CE, Moss SE (2005). "Annexins: linking Ca2+ signaling to membrane dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 449–61. doi:10.1038/nrm1661. PMID 15928709. S2CID 37526262.
Chang KS, Wang G, Freireich EJ, etal. (1992). "Specific expression of the annexin VIII gene in acute promyelocytic leukemia". Blood. 79 (7): 1802–10. doi:10.1182/blood.V79.7.1802.1802 . PMID 1313714.
Chambers JA, Gardner E, Hauptmann R, etal. (1993). "TaqI polymorphisms at the annexin VIII locus (ANX8)". Hum. Mol. Genet. 1 (7): 550. doi:10.1093/hmg/1.7.550 . PMID 1364010.
Hauptmann R, Maurer-Fogy I, Krystek E, etal. (1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". Eur. J. Biochem. 185 (1): 63–71. doi:10.1111/j.1432-1033.1989.tb15082.x . PMID 2530088.
Sarkar A, Yang P, Fan YH, etal. (1994). "Regulation of the expression of annexin VIII in acute promyelocytic leukemia". Blood. 84 (1): 279–86. doi:10.1182/blood.V84.1.279.279 . PMID 8018923.
Reutelingsperger CP, van Heerde W, Hauptmann R, etal. (1994). "Differential tissue expression of Annexin VIII in human". FEBS Lett. 349 (1): 120–4. Bibcode:1994FEBSL.349..120R. doi:10.1016/0014-5793(94)00559-1 . PMID 8045287. S2CID 8928858.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, etal. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, etal. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285 . PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, etal. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462 . PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, etal. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Stein T, Price KN, Morris JS, etal. (2006). "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer". Clin. Cancer Res. 11 (19 Pt 1): 6872–9. doi:10.1158/1078-0432.CCR-05-0547 . PMID 16203777.
Kimura K, Wakamatsu A, Suzuki Y, etal. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Goebeler V, Ruhe D, Gerke V, Rescher U (2006). "Annexin A8 displays unique phospholipid and F-actin binding properties". FEBS Lett. 580 (10): 2430–4. Bibcode:2006FEBSL.580.2430G. doi:10.1016/j.febslet.2006年03月07日6 . PMID 16638567. S2CID 22336528.

v t e PDB gallery
1w3w: THE 2.1 ANGSTROEM RESOLUTION STRUCTURE OF ANNEXIN A8 1w3w: THE 2.1 ANGSTROEM RESOLUTION STRUCTURE OF ANNEXIN A8 1w45: THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS. 1w45: THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.

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References

External links

Further reading