3alpha-hydroxycholanate dehydrogenase
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Class of enzymes
| 3-alpha-hydroxycholanate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.52 | ||||||||
| CAS no. | 9028-57-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a 3alpha-hydroxycholanate dehydrogenase (EC 1.1.1.52) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are the bile acid lithocholic acid and nicotinamide adenine dinucleotide (NAD+). Its products are dehydrolithocholic acid, NADH, and a proton.[1] [2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase. This enzyme is also called alpha-hydroxy-cholanate dehydrogenase.
Structural studies
[edit ]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1IHI .
References
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