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25O-NBcP

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Chemical compound
Pharmaceutical compound
25O-NBcP
Clinical data
Other namesNBcPr-2C-O
Identifiers
  • N-(2-cyclopropylbenzyl)-1-(2,4,5-trimethoxyphenyl)-2-aminoethane
CAS Number
PubChem CID
Chemical and physical data
Formula C21H27NO3
Molar mass 341.451g·mol−1
3D model (JSmol)
  • COc1cc(CCNCc2ccccc2C2CC2)c(OC)cc1OC
  • InChI=1S/C21H27NO3/c1-23-19-13-21(25-3)20(24-2)12-16(19)10-11-22-14-17-6-4-5-7-18(17)15-8-9-15/h4-7,12-13,15,22H,8-11,14H2,1-3H3
  • Key:ASIWTSUIYDTYFT-UHFFFAOYSA-N

25O-NBcP (NBcPr-2C-O) is a phenethylamine derivative from the 25-NB class. It acts as a potent agonist at the 5-HT2A receptor with weaker activity at 5-HT2B and 5-HT2C, and unlike the parent compound 2C-O, 25O-NBcP produces a head-twitch response in animal studies which often correlates with potential for psychedelic effects in humans.[1] [2]

See also

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References

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  1. WO 2022241006, Wallach J, McCorvy J, Halberstadt A, "Selective, Partial and Arrestin-Biased 5-HT2A Agonists with Utility in Various Disorders.", published 17 November 2022, assigned to Saint Joseph's University, The Medical College Of Wisconsin, Inc., The Regents Of The University Of California
  2. Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, et al. (July 2023). "Identification of 5-HT2A Receptor Signaling Pathways Responsible for Psychedelic Potential". bioRxiv 10.1101/2023.07.29.551106 .


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