(R)-2-hydroxy-fatty-acid dehydrogenase
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Class of enzymes
| (R)-2-hydroxy-fatty-acid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.98 | ||||||||
| CAS no. | 37250-32-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a (R)-2-hydroxy-fatty-acid dehydrogenase (EC 1.1.1.98) is an enzyme that catalyzes the chemical reaction
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The two substrates of this enzyme are (R)-2-hydroxystearic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 2-oxostearic acid, reduced NADH, and a proton. This reaction is important in fatty acid metabolism.[1] [2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include D-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.
See also
[edit ]- (S)-2-hydroxy-fatty-acid dehydrogenase which acts on the enantiomer of the hydroxy acid.
References
[edit ]- ↑ Enzyme 1.1.1.98 at KEGG Pathway Database.
- ↑ Levis GM (February 1970). "2-Hydroxy fatty acid oxidases of rat kidney". Biochemical and Biophysical Research Communications. 38 (3): 470–7. Bibcode:1970BBRC...38..470L. doi:10.1016/0006-291X(70)90737-0. PMID 5443694.
