While testing 400 different plant extracts and flavonoids, researchers from the Salk Institute discovered that yerba santa contains the
flavanone sterubin, which has neuroprotective and anti-inflammatory effects.
Hesperetin (4'-methoxy-5.7.3'-trihydroxyflavanone) is the prominent
flavanone and its glycosides which can be found in citrus fruits.
Health-promoting effects of the citrus
flavanone hesperidin.
Anti MRSA activity achieved by
flavanone is beneficial to the structure of A ring (5,7-dihydroxylation) and B ring (2',4'- or 2',6'-dihydroxylation), which is essential for significant activity (40).
In second phase, docking studies on
flavanone derivatives were conducted.
A prenylated
flavanone from Dalea elegans inhibits rhodamine 6G efflux and reverses fluconazole resistance in Candida albicans.
With this background in mind, the current study analyzed the protective effects of Hsd , as a major
flavanone constituent, by determining its effect on 6-OHDA-mediated oxidative stress generation, mitochondrial dysfunction, and apoptosis in human neuroblastoma SH-SY5Y cells.
Jimenez-Ferrer et al., "Isosakuranetin-5-O-rutinoside: A New
Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl," Molecules, vol.
Agarwal, "Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of
flavanone silibinin with flavanolignan mixture silymarin," Oncogene, vol.
Hesperidin, a naturally occurring
flavanone glycoside, is mainly found in citrus fruits [5].
Kim, "A newprenylated
flavanone from the roots of Sophora flavescens," Fitoterapia, vol.