Abstract:The genome of the type strain of Candida glabrata (CBS138, ATCC2001) contains homologs of most of the genes involved in mating in S. cerevisiae, starting with the mating pheromone and receptor genes. Only haploid cells are ever isolated, but C. glabrata strains of both mating types are commonly found, the type strain being MATalpha, and most others, such as BG2, MATa. No sexual cycle has been documented in this species. In order to understand which steps of the mating pathway are defective, we have analysed the expression of homologs of some of the key genes involved, and also production of mating pheromones and sensitivity to artificial pheromones.We show that cells of opposite mating-types express both pheromone receptor genes, and are insensitive to pheromones. Nonetheless, cells maintain specificity through regulation of the alpha1 and alpha2 genes, and more surprisingly, through differential splicing the a1 transcript.

Status: Published Type: Journal Article|Research Support, Non-u.s. Gov't PubMed ID: 18375614

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