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Cormack BP, Ghori N, Falkow S (1999) An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells. Science 285(5427):578-82
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Abstract:Candida glabrata is an important fungal pathogen of humans that is responsible for about 15 percent of mucosal and systemic candidiasis. Candida glabrata adhered avidly to human epithelial cells in culture. By means of a genetic approach and a strategy allowing parallel screening of mutants, it was possible to clone a lectin from a Candida species. Deletion of this adhesin reduced adherence of C. glabrata to human epithelial cells by 95 percent. The adhesin, encoded by the EPA1 gene, is likely a glucan-cross-linked cell-wall protein and binds to host-cell carbohydrate, specifically recognizing asialo-lactosyl-containing carbohydrates.
Status: Published Type: Journal article|Journal Article|Research Support, Non-u.s. Gov't PubMed ID: 10417386

Topics addressed in this paper
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Topics
Genes linked to topics
EPA1
(C. glabrata)
Adherence
Cross-species Expression
Fungal Related Genes/Proteins
Interactions with host
Mutants/Phenotypes
Protein Domains/ Motifs
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