Abstract:Candida albicans is termed a dimorphic fungus because it proliferates ineither a yeast form or a hyphal form. The switch between these forms is the result of a complex interplay of external and internal factors and is coordinated inpart by polarity-regulating proteins that are conserved among eukaryotic cells. However, yeast and hyphal cells are not the only morphological states of C. albicans. The opaque form required for mating, the pseudohyphal cell, and the chlamydospore represent distinct cell types that form in response to specific genetic or environmental conditions. In addition, hyperextended buds can form as a result of various cell cycle-related stresses. Recent studies are beginning to shed light on some of the molecular controls regulating the various morphogenetic forms of this fascinating human pathogen.

Status: Published Type: Journal article PubMed ID: 17506678

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