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Srikantha T, Borneman AR, Daniels KJ, Pujol C, Wu W, Seringhaus MR, Gerstein M, Yi S, Snyder M, Soll DR (2006) TOS9 regulates white-opaque switching in Candida albicans. Eukaryot Cell 5(10):1674-87
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Abstract:In Candida albicans, the a1-alpha2 complex represses white-opaque switching, as well as mating. Based upon the assumption that the a1-alpha2 corepressor complex binds to the gene that regulates white-opaque switching, a chromatinimmunoprecipitation-microarray analysis strategy was used to identify 52 genes that bound to the complex. One of these genes, TOS9, exhibited an expression pattern consistent with a "master switch gene." TOS9 was only expressed in opaque cells, and its gene product, Tos9p, localized to the nucleus. Deletion of the gene blocked cells in the white phase, misexpression in the white phase caused stable mass conversion of cells to the opaque state, and misexpression blocked temperature-induced mass conversion from the opaque state to the white state. A model was developed for the regulation of spontaneous switching between the opaque state and the white state that includes stochastic changes of Tos9p levels above and below a threshold that induce changes in the chromatin state of an as-yet-unidentified switching locus. TOS9 has also been referred to as EAP2 and WOR1.
Status: Published Type: Journal article PubMed ID: 16950924

Topics addressed in this paper
There are 54 different genes addressed in this paper.

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Topics
Genes linked to topics(#1-10)
ARH2
(C. albicans)		ASF1
(C. albicans)		AVT1
(C. albicans)		AVT7
(C. albicans)		C1_05200C
(C. albicans)		C1_05270C
(C. albicans)		C1_10140C
(C. albicans)		C2_04910W
(C. albicans)		C2_05380W
(C. albicans)		C2_08340C
(C. albicans)
Alias




DNA/RNA Sequence Features
Genome-wide Analysis
Phenotypic Switching
RNA Levels and Processing
Transcriptional Regulation

Topics
Genes linked to topics(#11-20)
C2_08350C
(C. albicans)		C2_09690C
(C. albicans)		C2_09810C
(C. albicans)		C2_09820W
(C. albicans)		C2_09860C
(C. albicans)		C2_09870W
(C. albicans)		CAG1
(C. albicans)		CEK2
(C. albicans)		CFL11
(C. albicans)		CPH1
(C. albicans)
Alias



DNA/RNA Sequence Features
Genome-wide Analysis
Phenotypic Switching
RNA Levels and Processing
Transcriptional Regulation

Topics
Genes linked to topics(#21-30)
CR_06020W
(C. albicans)		CR_07870W
(C. albicans)		DFG10
(C. albicans)		EFH1
(C. albicans)		FAR1
(C. albicans)		FGR23
(C. albicans)		HGT4
(C. albicans)		HYR4
(C. albicans)		IFI3
(C. albicans)		KIC1
(C. albicans)
Alias



DNA/RNA Sequence Features
Genome-wide Analysis
Phenotypic Switching
RNA Levels and Processing
Transcriptional Regulation
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  • To go to the Locus page for a gene, click on the gene name.

Topics
Genes linked to topics(#31-40)
LEU42
(C. albicans)		MFALPHA
(C. albicans)		MHP1
(C. albicans)		MTLA1
(C. albicans)		MTLA2
(C. albicans)		MTLALPHA2
(C. albicans)		NUS1
(C. albicans)		PGA55
(C. albicans)		PSO2
(C. albicans)		PTH2
(C. albicans)
Alias
DNA/RNA Sequence Features

Function/Process
Genome-wide Analysis
Mutants/Phenotypes
Phenotypic Switching
Protein Physical Properties




Protein-Nucleic Acid Interactions




RNA Levels and Processing

Regulatory Role




Strains/Constructs



Transcriptional Regulation

Topics
Genes linked to topics(#41-50)
RGS2
(C. albicans)		RHB1
(C. albicans)		ROM2
(C. albicans)		RXT3
(C. albicans)		SAC3
(C. albicans)		SAP98
(C. albicans)		SCP1
(C. albicans)		STE18
(C. albicans)		STE2
(C. albicans)		STE4
(C. albicans)
Alias


DNA/RNA Sequence Features
Genome-wide Analysis
Phenotypic Switching
RNA Levels and Processing
Transcriptional Regulation

Topics
Genes linked to topics(#51-54)
TRS33
(C. albicans)		WHI3
(C. albicans)		WOR1
(C. albicans)		orf19.566
(C. albicans)
Alias
Cellular Location
DNA/RNA Sequence Features
Function/Process
Fungal Related Genes/Proteins
Genome-wide Analysis
Mutants/Phenotypes
Phenotypic Switching
Post-Translational Modifications
Protein Domains/ Motifs
Protein Physical Properties
Protein-Nucleic Acid Interactions
RNA Levels and Processing
Regulation (Unspecified)
Regulatory Role
Strains/Constructs
Techniques and Reagents
Transcriptional Regulation
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