Abstract:The interaction of Candida species with their cognate host receptors is a key factor in the pathogenesis of different types of candidiasis. The recognition of different forms of Candida albicans by Toll-like receptors 2 and 4 on mononuclear leukocytes has recently been discovered to determine the function and activity of regulatory T-cells, determine the balance of Type 1 and Type 2 cytokines and, thereby, influence the antifungal activity of both the innate and adaptive immune response. Different forms of C. albicans are also recognized by different lectins that are expressed on the surface macrophages. C. albicans and Candida glabrata express the ALS (agglutinin-like sequence) and EPA (epithelial adhesin) families of adhesins, respectively. A key difference between C. glabrata and C. albicans is that EPA expression in C. glabrata is governed by sub-telomeric silencing, whereas ALS expression in C. albicans is regulated by other mechanisms.

Status: Published Type: Journal article PubMed ID: 16837237

• To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  displays other papers with information about that topic for that gene.
  displays other papers in CGD that are associated with that topic.
  The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.


• To go to the Locus page for a gene, click on the gene name.