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Heinsbroek SE, Brown GD, Gordon S (2005) Dectin-1 escape by fungal dimorphism. Trends Immunol 26(7):352-4
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Abstract:Candida albicans, a medically important fungus, exists primarily as yeast and filamentous forms. Its cell wall is rich in beta-glucans, which are recognized by a lectin-like innate immune receptor, Dectin-1. A recent study shows that exposure of glucan, by yeasts but not filaments, determines Dectin-1-dependent uptake by macrophages, and thus representsa novel immune evasion mechanism. Here, we discuss the insights these results provide in relation to macrophage interactions with C. albicans and pathogen entry.
Status: Published Type: Journal article|Review PubMed ID: 15922664

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