Abstract:Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, in Candida albicans, the RP regulon is controlled by the Myb domain protein Tbf1 working in conjunction with Cbf1. These two factors bind both the promoters of RP genes and the rDNA locus; Tbf1 activates transcription at these loci and is essential. Orthologs of Tbf1 bind TTAGGG telomeric repeats in most eukaryotes, and TTAGGG cis-elements are present upstream of RP genes in plants and fungi, suggesting that Tbf1 was involved in both functions in ancestral eukaryotes. In all Hemiascomycetes, Rap1 substituted Tbf1 at telomeres and, in the S. cerevisiae lineage, this substitution also occurred independently at RP genes, illustrating the extreme adaptability and flexibility of transcriptional regulatory networks.

Status: Published Type: Journal Article|Research Support, N.I.H., Extramural|Research Support, Non-U.S. Gov't PubMed ID: 18342603

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#1-10(C1_10350C-CRP1) #11-20(CR_07470W-PGA62) #21-30(PLB3-RPL14) #31-40(RPL15A-RPS12) #41-50(RPS14B-SAP10) #51-59(SEC65-orf19.632)

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Jump to Summary Chart for:

#1-10(C1_10350C-CRP1) #11-20(CR_07470W-PGA62) #21-30(PLB3-RPL14) #31-40(RPL15A-RPS12) #41-50(RPS14B-SAP10) #51-59(SEC65-orf19.632)

• To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  displays other papers with information about that topic for that gene.
  displays other papers in CGD that are associated with that topic.
  The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.


• To go to the Locus page for a gene, click on the gene name.