C. glabrata PDR1/CAGL0A00451g Literature Guide

Reference	Species	Other Genes Addressed
*Gale AN, et al.* (2023)** Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrata. mSphere :e0025423 CGD Papers Entry Pubmed Entry Web Supplement Data	C. glabrata	\|ATP1 \|ATP2 \|CAGL0J00297g \|CAGL0L03828g \|CDR1 \|CIN5 \|DAP1 \|ERG11 \|LSC2 \|RPL28 \|TRP1 \|TRP2 \|UPC2A
*Okamoto M, et al.* (2023)** In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility. J Fungi (Basel) 9(2) CGD Papers Entry Pubmed Entry	C. glabrata	\|CDR1 \|GEM1 \|MDM10 \|MDM12 \|MDM34 \|MMM1 \|PDH1
*Gaspar-Cordeiro A, et al.* (2022)** Zap1 is required for Candida glabrata response to fluconazole FEMS Yeast Res CGD Papers Entry Pubmed Entry	C. glabrata	\|CDR1 \|ZAP1
*Nikolov VN, et al.* (2022)** SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes. Nat Commun 13(1):1968 CGD Papers Entry Pubmed Entry	C. glabrata	\|RTT106 \|SNF2
Vu BG and Moye-Rowley WS (2022) Azole-resistant alleles of ERG11 in Candida glabrata trigger activation of the Pdr1 and Upc2A transcription factors Antimicrob Agents Chemother CGD Papers Entry Pubmed Entry	C. albicans	\|ERG11
C. glabrata	\|ERG11 \|UPC2A
*Ceballos-Garzon A, et al.* (2021)** Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant Candida glabrata J Antimicrob Chemother CGD Papers Entry Pubmed Entry	C. glabrata	\|CAGL0A04257g \|CAGL0F04631g \|CAGL0F04895g \|CAGL0I05060g \|CAGL0J05566g \|CAGL0J08591g \|CAGL0J09724g \|CAGL0J11440g \|CAGL0K00605g \|CAGL0L06182g \|CAGL0L10021g \|CAGL0L11440g \|CAGL0M08404g \|CRZ1 \|MORE
Simonicova L and Moye-Rowley WS (2020) Functional information from clinically-derived drug resistant forms of the Candida glabrata Pdr1 transcription factor. PLoS Genet 16(8):e1009005 CGD Papers Entry Pubmed Entry	C. glabrata	\|CDR1
*Galkina KV, et al.* (2019)** Deletion of CDR1 reveals redox regulation of pleiotropic drug resistance in Candida glabrata. Biochimie CGD Papers Entry Pubmed Entry	C. glabrata	\|CDR1 \|FLR1
*Nishimoto AT, et al.* (2019)** Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161. Antimicrob Agents Chemother 63(10) CGD Papers Entry Pubmed Entry	C. glabrata	\|CDR1 \|PDH1 \|SNQ2 \|UPC2A
*Khakhina S, et al.* (2018)** Positive autoregulation and repression of transactivation are key regulatory features of the Candida glabrata Pdr1 transcription factor. Mol Microbiol 107(6):747-764 CGD Papers Entry Pubmed Entry
*Ni Q, et al.* (2018)** CgPDR1 gain-of-function mutations lead to azole-resistance and increased adhesion in clinical Candida glabrata strains. Mycoses 61(7):430-440 CGD Papers Entry Pubmed Entry	C. glabrata	\|CDR1 \|EPA1 \|PDH1 \|SNQ2
*Paul S, et al.* (2018)** Negative regulation of Candida glabrata Pdr1 by the deubiquitinase subunit Bre5 occurs in a ubiquitin independent manner. Mol Microbiol 110(2):309-323 CGD Papers Entry Pubmed Entry	C. glabrata	\|BRE5 \|CDR1 \|PDH1 \|SNQ2 \|UBP3
*Tian Y, et al.* (2018)** Sequence modification of the master regulator Pdr1 interferes with its transcriptional autoregulation and confers altered azole resistance in Candida glabrata. FEMS Yeast Res 18(4) CGD Papers Entry Pubmed Entry	C. glabrata	\|GAL11A
*Whaley SG, et al.* (2018)** Relative Contribution of the ABC Transporters Cdr1, Pdh1, and Snq2 to Azole Resistance in Candida glabrata. Antimicrob Agents Chemother 62(10) CGD Papers Entry Pubmed Entry	C. glabrata	\|CDR1 \|PDH1 \|SNQ2
*Gupta P, et al.* (2017)** Functional analysis of selected deletion mutants in Candida glabrata under hypoxia. 3 Biotech 7(3):193 CGD Papers Entry Pubmed Entry	C. glabrata	\|ATM1 \|CCH1 \|CDR1 \|DUN1 \|ECM33 \|ECM7 \|ERG5 \|KRE1 \|KRE2 \|MID1 \|ROX1 \|UPC2B
*Nagayoshi Y, et al.* (2017)** Unexpected effects of azole transporter inhibitors on antifungal susceptibility in Candida glabrata and other pathogenic Candida species. PLoS One 12(7):e0180990 CGD Papers Entry Pubmed Entry	C. glabrata	\|CDR1 \|PDH1
C. albicans	\|C4_02040W_A \|CDR1 \|CDR11 \|CDR2
C. parapsilosis	\|CDR1
*Pais P, et al.* (2016)** Membrane Proteome-Wide Response to the Antifungal Drug Clotrimazole in Candida glabrata: Role of the Transcription Factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2. Mol Cell Proteomics 15(1):57-72 CGD Papers Entry Pubmed Entry Reference LINKOUT Web Supplement Data	C. glabrata	\|GAS1 \|TPO1_1 \|TPO1_2
*Vale-Silva LA, et al.* (2016)** Upregulation of the Adhesin Gene EPA1 Mediated by PDR1 in Candida glabrata Leads to Enhanced Host Colonization. mSphere 1(2) CGD Papers Entry Pubmed Entry	C. glabrata	\|EPA1
*Klimova N, et al.* (2014)** Phenotypic analysis of a family of transcriptional regulators, the zinc cluster proteins, in the human fungal pathogen Candida glabrata. G3 (Bethesda) 4(5):931-40 CGD Papers Entry Pubmed Entry Reference LINKOUT	C. glabrata	\|ARG81 \|CAGL0A00583g \|CAGL0D02904g \|CAGL0D03850g \|CAGL0E05434g \|CAGL0F02519g \|CAGL0F03025g \|CAGL0F06743g \|CAGL0G08844g \|CAGL0G09757g \|CAGL0H00396g \|CAGL0H01507g \|CAGL0H01683g \|CAGL0J07150g \|MORE
*Schwarzmuller T, et al.* (2014)** Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLoS Pathog 10(6):e1004211 CGD Papers Entry Pubmed Entry Web Supplement Data	C. glabrata	\|ACE2 \|ACO1 \|ACO2 \|ADA2 \|ADA3 \|ADP1 \|AFT2 \|ALG5 \|ALG6 \|AMT1 \|ANC1 \|ANP1 \|AP5 \|ARB1 \|MORE
*Culakova H, et al.* (2013)** Mutation of the CgPDR16 gene attenuates azole tolerance and biofilm production in pathogenic Candida glabrata. Yeast 30(10):403-14 CGD Papers Entry Pubmed Entry Reference LINKOUT	C. glabrata	\|PDR16
*Orta-Zavalza E, et al.* (2013)** Local silencing controls the oxidative stress response and the multidrug resistance in Candida glabrata. Mol Microbiol 88(6):1135-48 CGD Papers Entry Pubmed Entry Reference LINKOUT	C. glabrata	\|CDR1 \|CTA1 \|HST1 \|MSN4 \|RFM1 \|SIR2 \|SUM1
*Vale-Silva L, et al.* (2013)** Gain-of-function mutations in PDR1, a regulator of antifungal drug resistance in Candida glabrata, control adherence to host cells. Infect Immun 81(5):1709-20 CGD Papers Entry Pubmed Entry Reference LINKOUT
*Caudle KE, et al.* (2011)** Genomewide expression profile analysis of the Candida glabrata Pdr1 regulon. Eukaryot Cell 10(3):373-83 CGD Papers Entry Pubmed Entry Reference LINKOUT Data	C. glabrata	\|ATF2 \|CAGL0A01001g \|CAGL0A02134g \|CAGL0A02673g \|CAGL0A02882g \|CAGL0A03608g \|CAGL0A04323g \|CAGL0A04697g \|CAGL0A04807g \|CAGL0C01749g \|CAGL0C03916g \|CAGL0E00649g \|CAGL0E01441g \|CAGL0E01617g \|MORE
*Paul S, et al.* (2011)** Regulation of the CgPdr1 transcription factor from the pathogen Candida glabrata. Eukaryot Cell 10(2):187-97 CGD Papers Entry Pubmed Entry Reference LINKOUT	C. glabrata	\|CAGL0J06226g \|CDR1 \|GAL11A \|GAL11B \|HO \|PDH1 \|SRB8
*Ferrari S, et al.* (2009)** Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence. PLoS Pathog 5(1):e1000268 CGD Papers Entry Pubmed Entry Reference LINKOUT Reference LINKOUT	C. glabrata	\|CDR1 \|PDH1 \|SNQ2
*Thakur JK, et al.* (2008)** A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 452(7187):604-9 CGD Papers Entry Pubmed Entry Reference LINKOUT Reference LINKOUT	C. glabrata	\|GAL11A \|GAL11B \|MED1
C. albicans	\|MED15 \|MED15 \|MRR2 \|ZCF26 \|ZCF26 \|ZCF34
*Torelli R, et al.* (2008)** The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata. Mol Microbiol 68(1):186-201 CGD Papers Entry Pubmed Entry Reference LINKOUT	C. glabrata	\|SNQ2
*Tsai HF, et al.* (2006)** Candida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants. Antimicrob Agents Chemother 50(4):1384-92 CGD Papers Entry Pubmed Entry Reference LINKOUT	C. glabrata	\|CDR1 \|PDH1
*Edlind TD, et al.* (2005)** Promoter-dependent disruption of genes: simple, rapid, and specific PCR-based method with application to three different yeast. Curr Genet 48(2):117-25 CGD Papers Entry Pubmed Entry Reference LINKOUT	C. glabrata	\|ADE2 \|LEM3 \|RHO1 \|SLT2
C. albicans	\|LEM3 \|LEM3 \|MKC1 \|MKC1 \|RHO1 \|RHO1

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