Description:
Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation.
Participants:
(1) Integrin beta-3 (ITGB3)
(2) Talin-1 (TLN1)
(3) Docking protein 1 (DOK1)
(1) An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.
Oxley et al. J. Biol. Chem. (2008)
Other switches involving participants
Docking protein 1 (DOK1) - 4 more (view)
Integrin beta-3 (ITGB3) - 15 more (view)
Talin-1 (TLN1) - 3 more (view)
Other switches involving interfaces
PTB domain (IRS-1 type) - 12 more (view)
LIG_PTB_Phospho_1 - 18 more (view)
LIG_PTB_Apo_2 - 3 more (view)
