ELM - instance LIG_SxIP_EBH_1 in sequence P25054 at position 2801

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001285	P25054 APC APC_HUMAN	2801	2811	STSARPSQIPTPVNNNTKKR	TP	---	Homo sapiens (Human)	2843

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro	support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Honnappa,2005	support	certain
experimental	MI:0077	nuclear magnetic resonance	in vitro	Honnappa,2005	support	certain	InteractionDetection FeatureDetection
experimental	MI:0017	classical fluorescence spectroscopy	in vitro	Honnappa,2005	support	certain	InteractionDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Honnappa,2005	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Honnappa,2005	support	certain	FeatureDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000276:
ELM Switch SWTI000276
Phosphorylation of S2789 and S2793 adjacent to the EBH-binding motif of Adenomatous polyposis coli protein (APC), by, respectively, gradually reduces the affinity of its interaction with Microtubule-associated protein RP/EB family member 1 (MAPRE1).

o Pathways

KEGG: The sequence P25054 is implicated in the following 16 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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