ELM - instance DEG_SCF_TRCP1_1 in sequence P05923 at position 51

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001315	P05923 vpu VPU_HV1BR	51	56	RLIERAEDSGNESEGEISAL	TP	---	Human immunodeficiency virus type 1 (BRU ISOLATE)	81

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0077	nuclear magnetic resonance	in vitro	Coadou,2003	support	certain	InteractionDetection FeatureDetection
experimental	MI:0517	radiolabel	in vitro	Besnard-Guerin,2004	support	certain
experimental	MI:0663	confocal microscopy	in vivo/in vitro	Besnard-Guerin,2004	support	certain	InteractionDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000159:
ELM Switch SWTI000159
Dual phosphorylation of S52 and S56 in the TrCP1-binding motif of Protein Vpu (vpu) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement