Description:
Dual phosphorylation of S52 and S56 in the TrCP1-binding motif of Protein Vpu (vpu) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Participants:
(1) Protein Vpu (vpu)
(2) F-box/WD repeat-containing protein 1A (BTRC)
(1) HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates.
Besnard-Guerin et al. J. Biol. Chem. (2004)
Other switches involving participants
F-box/WD repeat-containing protein 1A (BTRC) - 17 more (view)
Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
DEG_SCF_TRCP1_1 - 17 more (view)
