ELM - instance LIG_NRBOX in sequence P48552 at position 379

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000775	P48552 NRIP1 NRIP1_HUMAN	379	385	QAANNSLLLHLLKSQTIPKP	TP	2GPO pdb:2GPO	Homo sapiens (Human)	1158

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0114	x-ray crystallography	in vitro	Wang,2006	support	certain	InteractionDetection FeatureDetection
experimental	MI:0018	two hybrid	in vivo	Heery,1997	support	certain	InteractionDetection
not annotated	not specified	not specified	not specified

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000254:
ELM Switch SWTI000254
Binding of the 50114" target="_blank">estrogen ligand to the nuclear Estrogen receptor (ESR1) makes the binding site for the NRBOX motif of Nuclear receptor-interacting protein 1 (NRIP1) accessible.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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