54th Annual Meeting of the Japanese Society of Neurology

Mechanism of regional spread in ALS

May 30 (Thu) 9:00-9:50 Room4 (Hall B7 (2))

Chair:

Takanori Yokota Department of Neurology and Neurological Science,
Tokyo Medical and Dental University

Speaker:

John Ravits University of California San Diego, USA

Advances in inherited neuropathies

May 31 (Fri) 9:00-9:50 Room4 (Hall B7 (2))

Chair:

Masanori Nakagawa Kyoto Prefectural University of Medicine

Speaker:

Michael E Shy Department of Neurology,
University of Iowa Carver College of Medicine, Iowa, USA

Amyotrophic lateral sclerosis - What have we learned?

June 1 (Sat) 8:00-8:50 Room4 (Hall B7 (2))

Chair:

Satoshi Kuwabara Chiba University

Speaker:

Matthew C. Kiernan Neuroscience Research Australia and Prince of Wales Clinical School, University of New South Wales, Australia

Neuroimaging of Dementia

June 1 (Sat) 14:40-15:30 Room4 (Hall B7 (2))

Chair:

Mikio Shoji Hirosaki University Graduate School of Medicine

Speaker:

Martin Rossor Clinical Neurology,
The National Hospital for Neurology and Neurosurgery, UK

Developing Neurology in the World

Chairs:

Ryuji Kaji Department of Clinical Neuroscience, Institute of Health Biosciences,
The University of Tokushima Graduate School

Raad Shakir Imperial College NHS Trust, Charing Cross Hospital, London, UK /
World Federation of Neurology

The Japanese Society of Neurology and developing neurology in the world

Speaker:

Hidehiro Mizusawa Meeting President, the 54th Annual Meeting of the Japanese Society of Neurology/President/CEO, the Japanese Society of Neurology/Department of Neurology and Neurological Science, Tokyo Medical and Dental University

Developing neurology in the world
WFN/European view

Speaker:

Raad Shakir Imperial College NHS Trust, Charing Cross Hospital, London, UK /
World Federation of Neurology

Developing neurology in Asia and Oceania

Speaker:

Man Mohan Mehndiratta

Asian Oceanian Association of Neurology (AOAN),
World Federation of Neurology, India

The Panamerican Federation of Neurological Societies a WFN Initiative and Neurology in the Central America

Speaker:

Marco T. Medina Facalty of Medical Sciences,
National Autonomous University of Honduras, Honduras

The development of neurology in Central and South America

Speaker:

Renato J. Verdugo Service of Neurology, Faculty of Medicine,
Clinica Alemana-Universidad del Desarrollo, Santiago, Chile

Developing neurology in Sub-Saharan Africa

Speaker:

Amadou Gallo Diop Dept of Neurology, University Hospital of Fann, Dakar, Senegal

Spinocerebellar Ataxia: Research Progress and Developing Treatment

Chairs:

Hidehiro Mizusawa Department of Neurology and Neurological Science,
Tokyo Medical and Dental University

Tetsuo Ashizawa McKnight Brain Institute, University of Florida, USA

SCA13 and channel disorders

Speaker:

Stefan-M. Pulst University of Utah, Salt Lake City, USA

Toward understanding an treating the polyglutamine ataxia spinocerebellar ataxia type 3 (SCA3)

Speaker:

Henry Paulson Department of Neurology, University of Michigan, USA

Spinocerebellar ataxia type 31 (SCA31) and non-coding repeat expansion disorders

Speaker:

Kinya Ishikawa Department of Neurology and Neurological Science, Tokyo Medical and Dental University

Multiple system atrophy (MSA)

Speaker:

Shoji Tsuji Neuroscience, Graduate School of Medicine, The University of Tokyo

The clinical research consortium for spinocerebellar ataxias in US

Speaker:

Tetsuo Ashizawa McKnight Brain Institute, University of Florida, USA

Cerebral Small Vessel Disease -Up to Date-

Chairs:

Shinichiro Uchiyama Department of Neurology, Tokyo Women's Medical University

Reinhold Schmidt University Clinic of Neurology, Clinical Division of Neurogeriatrics,
Medical University Graz, Austria

An overview on recent advances in age-related cerebral small vessel disease

Speaker:

Reinhold Schmidt University Clinic of Neurology, Clinical Division of Neurogeriatrics,
Medical University Graz, Austria

CADASIL, recent progress

Speaker:

Anne Joutel INSERM, University of Paris, France

An emerging molecular mechanism for the cerebral small vessel disease

Speaker:

Osamu Onodera Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute, Niigata University

Cerebral Small Vessel Disease and Cognitive Impairment - Insight into prevention and treatment -

Speaker:

Ken Nagata Department of Neurology, Research Institute for Brain and Blood Vessels

Oral Session

Spinocerebellar Ataxias and Related Disorders in East Asia

Chairs:

Ching Piao Tsai The Neurological Institute, Veterans General Hospital, Taipei, Taiwan

Hidenao Sasaki Hokkaido University, Graduate School of Medicine / School of Medicine

SCA6: Lessons from genetic mouse models

Speaker:

Kei Watase Center for Brain Integration Research, Tokyo Medical and Dental University

Movement Disorders in spinocerebellar ataxias

Speaker:

Beom S. Jeon Department of Neurology, College of Medicine, Seoul National University, Korea

Identification of TGM6 as a novel causative gene of SCA35 and its implication for pathogenesis

Speaker:

Bei-sha Tang Department of Neurology, Xiangya Hospital, Central South University / Neurodegenerative Disorders Research Center, Central South University / State Key Lab of Medical Genetics, Central South University, Changsha, Hunan, China

Mutations in KCND3 cause spinocerebellar ataxia type 22

Speaker:

Bing-wen Soong Dept of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan

Poster Session

Chair:

Hidenao Sasaki Hokkaido University, Graduate School of Medicine

Using Next-Generation Sequencing as a genetic diagnostic tool in rare autosomal recessive neurological Mendelian disorders

Speaker:

Hong Jiang Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China / Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, China

Mutations in GNB4 cause Dominant Intermediate Charcot-Marie-Tooth disease

Speaker:

Yi-Chung Lee Department of Neurology, Taipei Veterans General Hospital /
Department of Neurology, National Yang-Ming University, Taipei, Taiwan

Comprehensive genetic analysis of autosomal dominant spinocerebellar ataxia using a next generation sequencer

Speaker:

Yujiro Higuchi Department of Neurology and Geriatrics,
Kagoshima University Graduate School of Medical and Dental Science

Analysis of autosomal dominant spinocerebellar ataxias using Next-Generation sequencing

Speaker:

Kokoro Ozaki Department of Neurology and Neurological Science,
Tokyo Medical and Dental University

A mir-153 binding site polymorphism in SNCA in a patient with Parkinson disease

Speaker:

Han-Joon Kim Departments of Neurology and Movement Disorder Center, Parkinson Study Group, and Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Korea

Structural Template for Neurodegeneration -From Network to Clinical Manifestations-

May 30 (Thu) 10:00-11:50 Room10 (G502)

Chairs:

Shigeo Murayama The Brain Bank for Aging Research of Tokyo Metropolitan Healthy Longevity Medical Center

Toshiki Uchihara Laboratory of Structural Neuropathology, Tokyo Metropolitan Institute of Medical Science

Neuroanatomy of regional progression in the human brain and spinal cord

Speaker:

Kelly Del Tredici-Braak

Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany

Axonal α-synuclein and dendritic tau: contrasting spreads in neurons

Speaker:

Toshiki Uchihara Laboratory of Structural Neuropathology,
Tokyo Metropolitan Institute of Medical Science

Transmission and propagation of tau pathology in transgenic mouse brain

Speaker:

Markus Tolnay Institute of Pathology, Basel University Hospital, Basel, Switzerland

Spread of TDP-43 pathology in non-human primate model of ALS

Speaker:

Takanori Yokota Department of Neurology and Neurological Science, Tokyo Medical and Dental University

Basics of Epilepsy Treatment and Advances of Seizure Focus Localization

May 31 (Fri) 13:30-15:20 Room6 (Hall B5 (2))

Chairs:

Sadatoshi Tsuji International University of Health and Welfare

Akio Ikeda Department of Neurology,
Kyoto University Hospital and Graduate School of Medicine

Current antiepileptic treatment in women of child-bearing age

Speaker:

Torbjörn Tomson Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

Routine scalp EEG: The diagnostic role in epilepsy

Speaker:

Ayumu Onuma Department of Neurology, Kohnan Hospital

Usefulness of long term video EEG monitoring and factors for consideration

Speaker:

Hiroshi Shigeto Fukuoka Sanno Hospital

Progress in functional neuroimaging of epilepsy

Speaker:

Hiroshi Matsuda Integrative Brain Imaging Center, National Center of Neurology and Psychiatry

The role of neuropsychological examinations

Speaker:

Mitsuhiko Yamano Central Japan Railway Company, Shizuoka Health Care Center

Pathogenesis and Treatment of NMO

May 31 (Fri) 13:30-15:20 Room7 (Hall D7)

Chairs:

Yasuto Itoyama National Center Hospital, National Center of Neurology and Psychiatry

Makoto Matsui Department of Neurology, Kanazawa Medical University

Clinical spectrum of NMO: How broad is it?

Speaker:

Brian G. Weinshenker

Department of Neurology, Mayo Clinic, Rochester MN, USA

Neuropathology of NMO: a nosological consideration

Speaker:

Kazuo Fujihara Department of MS Therapeutics, Tohoku University Graduate School of Medicine

NMO pathogenesis mechanisms and new therapeutic approaches

Speaker:

Alan S. Verkman University of California, San Francisco, USA

The role of IL-6 dependent plasmablasts in the pathogenesis of NMO

Speaker:

Takashi Yamamura Department of Immunology, National Institute of Neuroscience, NCNP

Gene Silencing Therapy for Neurological Diseases

May 31 (Fri) 13:30-15:20 Room9 (Hall D1)

Chairs:

Beverly L. Davidson Department of Neurology, University of Iowa, USA

Shinichi Takeda National Center of Neurology and Psychiatry

RNAi medicine for the brain

Speaker:

Beverly L. Davidson University of Iowa, Iowa, USA

Advances in RNA interference (RNAi) therapeutics

Speaker:

Muthiah Manoharan Alnylam Pharmaceuticals, Cambridge, MA, USA

Antisense oligonucleotide therapies for the treatment of neurodegenerative diseases

Speaker:

C. Frank Bennett Isis Pharmaceuticals Inc., USA

A new class of oligonucleotide drug

Speaker:

Takanori Yokota Department of Neurology and Neurological Science, Tokyo Medical and Dental University

Recent Progress in Multiple System Atrophy

May 31 (Fri) 13:30-15:20 Room13 (G701)

Chairs:

Hideki Mochizuki Department of Neurology, Osaka University Graduate School of Medicine

Atsushi Takeda Department of Neurology, Tohoku University School of Medicine

Pathogenesis of multiple system atrophy

Speaker:

Takafumi Hasegawa Department of Neurology, Tohoku University School of Medicine

Genetics from familial multiple system atrophy

Speaker:

Jun Goto Department of Neurology, The University of Tokyo Hospital

Neuroimaging of multiple system atrophy

Speaker:

A. Jon Stoessl The Pacific Parkinson's Research Centre and National Parkinson Foundation Centre of Excellence at UBC & Vancouver Coastal Health, Canada

Mesenchymal stem cells as a potential therapeutic candidate of multiple system atrophy

Speaker:

Phil Hyu Lee Department of Neurology, Yonsei University College of Medicine / Severance Biomedical Science Institute, Yonsei University, Seoul, Korea

Vascular Dementia and Its Associated Conditions -Vascular Cognitive Impairment (VCI)

June 1 (Sat) 8:00-9:50 Room6 (Hall B5 (2))

Chairs:

Hidekazu Tomimoto Department of Neurology, Mie University Graduate School of Medicine

Osamu Onodera Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute, Niigata University

Overview of the neuropathology of vascular cognitive disorders

Speaker:

Raj N Kalaria Institute for Ageing and Health, NIHR Biomedical Research Building, Newcastle University, Newcastle upon Tyne, UK

Chronic cerebral hypoperfusion and dementia

Speaker:

Kenichiro Yata Department of Neurology, Mie University Graduate School of Medicine

Cerebral amyloid angiopathy and cognitive impairment

Speaker:

Masafumi Ihara Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center

Vascular cognitive impairment (VCI) and gene

Speaker:

Atsushi Watanabe National Center for Geriatrics and Gerontology, Laboratory of Research Advancement

Subgroups of AD associated with diabetes mellitus based on brain imaging

Speaker:

Haruo Hanyu Department of Geriatric Medicine, Tokyo Medical University

Non-coding Repeat Expansion Disorders

June 1 (Sat) 8:00-9:50 Room9 (Hall D1)

Chairs:

Kinji Ohno Division of Neurogenetics, Nagoya University Graduate School of Medicine

Tohru Matsuura Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Repeat-associated diseases, mutagenesis, pathogenesis, and therapeutic avenues

Speaker:

Christopher E. Pearson

The Reasearch Institute, The Hospital for Sick Children, Toronto, Canada

Spinocerebellar ataxia type 31

Speaker:

Kinya Ishikawa Department of Neurology and Neurological Science,
Tokyo Medical and Dental University

Clinical features of novel ALS/SCA crossroad mutation Asidan (SCA36)

Speaker:

Koji Abe Department of Neurology, Okayama University

Found in translation: Novel disease mechanisms in Fragile X Tremor Ataxia Syndrome

Speaker:

Peter K. Todd The Bucky and Patti Harris Professor of Neurology, University of Michigan Medical School, USA

The expanded GGGGCC repeat in C9orf72 is translated into aggregating dipeptide-repeat proteins in FTLD/ALS

Speaker:

Dieter Edbauer Ludwig-Maximilians Universität München, Munich, Germany