Warning: The NCBI web site requires JavaScript to function. more...

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Gene

Genes and mapped phenotypes

Search database

Search term

Showing Current items.

Sample GeneRIFs

TP53 tumor protein p53 [Homo sapiens (human)]

Gene ID: 7157
GeneRIF: p53 tetramers induce rapid apoptosis and cell growth arrest, while a monomeric variant is functionally inactive, supporting cell growth.
PubMed Title: p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis. Fischer NW, Prodeus A, Malkin D, Gariepy J.

Polg polymerase (DNA directed), gamma [Mus musculus (house mouse)]

Gene ID: 18975
GeneRIF: POLG-mutant mice exhibited characteristic behavioral phenotypes, distorted day-night rhythm and robust periodic activity pattern associated with estrous cycle. Abnormal behaviors were worsened by tricyclic antidepressants and improved by lithium.
PubMed Title: Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Kasahara T, Kubota M, Miyauchi T, Noda Y, Mouri A, Nabeshima T, Kato T.

Prkaca protein kinase cAMP-activated catalytic subunit alpha [Rattus norvegicus (Norway rat)]

Gene ID: 25636
GeneRIF: PKA regulates IP3R1 signaling with PP1 and PP2A in rat brain
PubMed Title: Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex. DeSouza N, Reiken S, Ondrias K, Yang YM, Matkovich S, Marks AR.

PHYB phytochrome B [Arabidopsis thaliana (thale cress)]

Gene ID: 816394
GeneRIF: PhyB inhibits the regulatory activity of PIF1 and PIF3 by releasing them from their DNA targets.
PubMed Title: Phytochrome B inhibits binding of phytochrome-interacting factors to their target promoters. Park E, Park J, Kim J, Nagatani A, Lagarias JC, Choi G.

Abl tyrosine kinase [Drosophila melanogaster (fruit fly)]

Gene ID: 45821
GeneRIF: Abl acts apically to suppress the accumulation of both Enabled (Ena) and actin in mesodermal cells during ventral furrow formation
PubMed Title: Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Fox DT, Peifer M.

Revised May 15, 2018

Account

Gene

Genes and mapped phenotypes

Sample GeneRIFs

Supplemental Content