Plant immune receptors built in silico and evolved in vivo
Reprogramming of plant nucleotide-binding leucine-rich immune receptors has long been limited by natural receptor diversity and hard-to-engineer recognition surfaces. A novel approach combines de novo protein design with directed evolution in planta to build synthetic plant immune receptors that detect diverse pathogen proteins, enabling on-demand design and refinement of resistance genes.
- Jonathan D. G. Jones
- He Zhao