Pathogenesis articles from across Nature Portfolio

Nucleic acid sensing is emerging as an important contributor to inflammation and tissue injury in the kidney. Here, the authors provide an overview of key DNA and RNA sensors, discuss evidence of their involvement in kidney pathology and consider the potential of these pathways as therapeutic targets.

Ivashkiv discusses recent advances in rheumatoid arthritis research using state-of-the-art single-cell and spatial transcriptomics and organoid systems, and discusses how these insights can be leveraged to further delineate disease biology and therapeutic opportunities.

SARS-CoV-2 ORF3a variations from the Delta variant differentiate it from other variants of concern; these mutations promote lysosome damage and multimodal cell death activation associated with disease severity.

Tipack Shanmugam discusses a study showing that microparticles released from atherosclerotic plaque can increase thrombotic risk and proposes that these extracellular vesicles might be therapeutically altered to prevent plaque rupture.

Tsiartas and Bennett discuss the discovery that atheroclerotic plaque vulnerability to rupture arises from the interaction between plaque composition and vessel biomechanics.

Two studies published in Science explore how 3D chromatin organization and structure can influence cardiac development and promote heart failure.

The identification of IRAK2 deficiency reveals how impaired Myddosome signalling can paradoxically promote interferon-driven inflammation, which expands the spectrum of monogenic immune dysregulation and underscores the importance of detecting structural variants in unsolved inborn errors of immunity.

Human brain organoids reveal how Ebola virus establishes persistent infection within the immune-privileged environment of the central nervous system.