Is it possible to directly connect my protein protein interaction network with the Reactome database or do I have to extract the required data and separately build the graph?

Yes, you can directly query in our graph database, for example:

 
MATCH (ref1:ReferenceEntity)<-[:referenceentity]-(p1:entitywithaccessionedsequence)<-[:input|output|catalystactivity|physicalentity|entityfunctionalstatus|diseaseentity|regulatedby|regulator|hascomponent|hasmember|hascandidate|repeatedunit*]-(reaction:reactionlikeevent)-[:input|output|catalystactivity|physicalentity|entityfunctionalstatus|diseaseentity|regulatedby|regulator|hascomponent|hasmember|hascandidate|repeatedunit*]->(p2:EntityWithAccessionedSequence)-[:referenceEntity]->(ref2:ReferenceEntity) 
WHERE ref1.databaseName = 'UniProt' AND ref2.databaseName = 'UniProt' AND ref1.identifier = 'P60484’ AND ref2.identifier = 'P42685' 
MATCH eventPath=(reaction)<-[:hasevent*]-(pathway) UNWIND (nodes(eventPath)) as p RETURN DISTINCT p.stId

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