checksum
27305B723043BF6C
comment
-
FUNCTION Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity).SUBUNIT Homodimer (PubMed:17897942). Interacts (via PDZ2 domain) with TJP1/ZO1 (via PDZ2 domain) (PubMed:17897942). Interacts with OCLN (By similarity). Interacts with UBN1 (PubMed:18823282). Interacts with SAFB in the nucleus (By similarity). Interacts with SCRIB (PubMed:15975580). Interacts with USP53 (via the C-terminal region) (By similarity). Interacts with claudins, including CLDN1, CLDN2, CLDN3, CLDN5 and CLDN7 (PubMed:12704386). Interacts with CLDN18 (By similarity). Interacts (via N-terminus) with CTNNA1 (By similarity).INTERACTION Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. Localizes to tight junctions during initial stages of their formation (By similarity).ALTERNATIVE PRODUCTS This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.DISEASE The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative splicing of isoform A1.MISCELLANEOUS Produced by alternative splicing of isoform A1.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative splicing of isoform C1.SIMILARITY Belongs to the MAGUK family.
databaseName
UniProt
dbId
68288
description
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recommendedName: fullName evidence="20"Tight junction protein 2 alternativeName: fullName evidence="18"Tight junction protein ZO-2 alternativeName: Zona occludens protein 2 alternativeName: Zonula occludens protein 2
displayName
UniProt:Q9UDY2 TJP2
identifier
Q9UDY2
isSequenceChanged
false
keyword
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3D-structure
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Alternative promoter usage
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Alternative splicing
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Cell junction
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Cell membrane
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Disease variant
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Intrahepatic cholestasis
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Membrane
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Nucleus
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Phosphoprotein
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Proteomics identification
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Reference proteome
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Repeat
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SH3 domain
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Tight junction
moleculeType
Protein
schemaClass
ReferenceGeneProduct
secondaryIdentifier
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ZO2_HUMAN
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A2A3H9
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B7Z2R8
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B7Z7T6
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F5H301
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F5H886
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Q15883
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Q5VXL0
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Q5VXL1
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Q8N756
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Q8NI14
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Q99839
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Q9UDY0
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Q9UDY1
sequenceLength
1190
stId
uniprot:Q9UDY2