chain
-
initiator methionine:1
-
chain:2-227
checksum
569E405EB7C801D0
comment
-
FUNCTION Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091).SUBUNIT Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13 (PubMed:21081504, PubMed:22114354, PubMed:22228767, PubMed:25997101). This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:21081504, PubMed:22114354, PubMed:22228767, PubMed:25997101). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form (By similarity). Interacts with IMMT/MIC60.SUBUNIT (Microbial infection) Interacts with human cytomegalovirus protein UL13; this interaction alters cristae architecture.INTERACTION Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue.SIMILARITY Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic19 subfamily.
databaseName
UniProt
dbId
223361
description
-
recommendedName: MICOS complex subunit MIC19 alternativeName: Coiled-coil-helix-coiled-coil-helix domain-containing protein 3
displayName
UniProt:Q9NX63 CHCHD3
identifier
Q9NX63
isSequenceChanged
false
keyword
-
Acetylation
-
Cytoplasm
-
Disulfide bond
-
Host-virus interaction
-
Lipoprotein
-
Membrane
-
Mitochondrion
-
Mitochondrion inner membrane
-
Myristate
-
Nucleus
-
Phosphoprotein
-
Proteomics identification
-
Reference proteome
-
Repressor
-
Transcription
-
Transcription regulation
moleculeType
Protein
otherIdentifier
-
11726318_s_at
-
11753342_x_at
-
11753592_x_at
-
11757083_s_at
-
11760429_at
-
1676_s_at
-
17063047
-
17063066
-
200689_3p_x_at
-
200689_PM_x_at
-
200689_x_at
-
211345_3p_x_at
-
211345_PM_x_at
-
211345_x_at
-
211927_3p_x_at
-
211927_PM_x_at
-
211927_x_at
-
217972_PM_at
-
217972_at
-
2402993
-
2402994
-
2402995
-
3073634
-
3073643
-
3073650
-
3073663
-
3073675
-
3073698
-
3073699
-
3073700
-
3073701
-
3073703
-
3073704
-
3073713
-
3073717
-
3073722
-
3073723
-
3073750
-
3073751
-
3073752
-
3073753
-
3073754
-
3073755
-
3073756
-
3073757
-
3073758
-
3073760
-
3234481
-
3375809
-
3375811
-
3375815
-
3375816
-
3375820
-
3375822
-
3375824
-
3375826
-
3988067
-
3988082
-
3988084
-
46233_at
-
54927
-
8143028
-
8143035
-
A_23_P13344
-
A_23_P251927
-
A_24_P287198
-
A_24_P467358
-
GE55487
-
GE61363
-
GO:0001401
-
GO:0005515
-
GO:0005634
-
GO:0005737
-
GO:0005739
-
GO:0005743
-
GO:0007005
-
GO:0007007
-
GO:0008053
-
GO:0016020
-
GO:0019902
-
GO:0042407
-
GO:0044284
-
GO:0060090
-
GO:0061617
-
GO:0070062
-
GO:0140275
-
HMNXSV003038176
-
HMNXSV003051962
-
HMNXSV003053972
-
ILMN_1673026
-
ILMN_1680437
-
M55409_s_at
-
TC11003185.hg
-
TC11003483.hg
-
g8923389_3p_at
schemaClass
ReferenceGeneProduct
sequenceLength
227
stId
uniprot:Q9NX63