UniProt:Q9NTN3 SLC35D1

chain
  • chain:1-355
checksum CAFF15D49605CA27
comment
  • FUNCTION Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar (PubMed:16965264, PubMed:17599910, PubMed:31423530). Transports various UDP-sugars including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides (PubMed:11322953, PubMed:16965264, PubMed:17599910, PubMed:17952091, PubMed:31423530). May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics (PubMed:16965264, PubMed:17599910). Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity).CATALYTIC ACTIVITY UDP-N-acetyl-alpha-D-glucosamine(in) + UDP-alpha-D-glucuronate(out) = UDP-N-acetyl-alpha-D-glucosamine(out) + UDP-alpha-D-glucuronate(in)CATALYTIC ACTIVITY UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-glucuronate(out) = UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-glucuronate(in)CATALYTIC ACTIVITY UMP(out) + UDP-N-acetyl-alpha-D-glucosamine(in) = UMP(in) + UDP-N-acetyl-alpha-D-glucosamine(out)CATALYTIC ACTIVITY UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)CATALYTIC ACTIVITY UMP(out) + UDP-alpha-D-glucuronate(in) = UMP(in) + UDP-alpha-D-glucuronate(out)CATALYTIC ACTIVITY UMP(out) + UDP-alpha-D-galactose(in) = UMP(in) + UDP-alpha-D-galactose(out)CATALYTIC ACTIVITY UMP(out) + UDP-alpha-D-glucose(in) = UMP(in) + UDP-alpha-D-glucose(out)CATALYTIC ACTIVITY UDP-alpha-D-xylose(in) + UMP(out) = UDP-alpha-D-xylose(out) + UMP(in)CATALYTIC ACTIVITY UDP-beta-L-arabinopyranose(in) + UMP(out) = UDP-beta-L-arabinopyranose(out) + UMP(in)CATALYTIC ACTIVITY UDP-beta-L-arabinofuranose(in) + UMP(out) = UDP-beta-L-arabinofuranose(out) + UMP(in)BIOPHYSICOCHEMICAL PROPERTIES kcat is 0.1 sec(-1) with UDP-alpha-D-glucuronate as substrate. kcat is 0.4 sec(-1) with UDP-N-acetyl-alpha-D-glucosamine as substrate. kcat is 0.3 sec(-1) with UDP-N-acetyl-alpha-D-galactosamine as substrate. kcat is 0.2 sec(-1) with UDP-alpha-D-xylose as substrate. kcat is 0.1 sec(-1) with UDP-beta-L-arabinopyranose as substrate. kcat is 0.2 sec(-1) with UDP-alpha-D-glucose as substrate. kcat is 0.2 sec(-1) with UDP-alpha-D-galactose as substrate.SUBCELLULAR LOCATION Ubiquitous.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TPT transporter family. SLC35D subfamily.CAUTION The use of uridine 5'-monophosphate (UMP) as a counter-anion is disputed and needs further investigation.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 66958
description
  • recommendedName: fullName evidence="11"Nucleotide sugar transporter SLC35D1 alternativeName: Solute carrier family 35 member D1 alternativeName: UDP-galactose transporter-related protein 7 shortName evidence="10"UGTrel7 alternativeName: UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter shortName: UDP-GlcA/UDP-GalNAc transporter
displayName UniProt:Q9NTN3 SLC35D1
geneName
  • SLC35D1
  • KIAA0260
  • UGTREL7
identifier Q9NTN3
isSequenceChanged false
keyword
  • Alternative splicing
  • Disease variant
  • Dwarfism
  • Endoplasmic reticulum
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Sugar transport
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9939033] Weiser, Joel, 2025年02月21日
moleculeType Protein
name
  • SLC35D1
otherIdentifier
  • 11736468_at
  • 11736469_a_at
  • 11736470_at
  • 16688269
  • 209711_PM_at
  • 209711_at
  • 209712_PM_at
  • 209712_at
  • 209713_PM_s_at
  • 209713_s_at
  • 23169
  • 2417099
  • 2417100
  • 2417101
  • 2417102
  • 2417103
  • 2417106
  • 2417113
  • 2417115
  • 2417118
  • 2417120
  • 2417121
  • 2417122
  • 2417123
  • 2417124
  • 2417125
  • 2417128
  • 2417129
  • 7916808
  • A_23_P357929
  • A_24_P208091
  • D87449_at
  • GE57403
  • GE79365
  • GO:0005461
  • GO:0005462
  • GO:0005463
  • GO:0005783
  • GO:0005789
  • GO:0005794
  • GO:0015165
  • GO:0015297
  • GO:0015780
  • GO:0015787
  • GO:0015789
  • GO:0016020
  • GO:0048706
  • GO:0048856
  • GO:0050650
  • GO:0055085
  • GO:0090481
  • GO:1901135
  • GO:1990569
  • HMNXSV003029976
  • Hs.82635.0.S2_3p_at
  • Hs.82635.0.S3_3p_at
  • ILMN_2057768
  • PH_hs_0004734
  • TC01002754.hg
  • TC01005544.hg
  • g11463948_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • S35D1_HUMAN
  • A8K185
  • B7Z3X2
  • Q52LU5
  • Q92548
sequenceLength 355
species [Species:48887] Homo sapiens
stId uniprot:Q9NTN3
url http://purl.uniprot.org/uniprot/Q9NTN3
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