checksum
5B0C366552774835
comment
-
FUNCTION Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12036956, PubMed:12226107, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12036956, PubMed:12226107).CATALYTIC ACTIVITY all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)CATALYTIC ACTIVITY 11-cis-retinol + NADP(+) = 11-cis-retinal + NADPH + H(+)CATALYTIC ACTIVITY 9-cis-retinol + NADP(+) = 9-cis-retinal + NADPH + H(+)CATALYTIC ACTIVITY 13-cis-retinol + NADP(+) = 13-cis-retinal + NADPH + H(+)ACTIVITY REGULATION SELENOF decreases the retinol dehydrogenase activity.BIOPHYSICOCHEMICAL PROPERTIES Vmax is measured per mg microsomal protein.PATHWAY Cofactor metabolism; retinol metabolism.SUBUNIT Interacts with SELENOF.INTERACTION Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes.INDUCTION By androgens in prostate cancer cells.PTM Not glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols.SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family.CAUTION In contrast to mouse, human RDH11 exhibits little or no activity towards toxic lipid peroxidation products, such as nonanal or 4-hydroxy-nonenal.
databaseName
UniProt
dbId
99769
description
-
recommendedName: Retinol dehydrogenase 11 ecNumber evidence="3 4"1.1.1.300 alternativeName: fullName evidence="8"Androgen-regulated short-chain dehydrogenase/reductase 1 alternativeName: HCV core-binding protein HCBP12 alternativeName: Prostate short-chain dehydrogenase/reductase 1 alternativeName: fullName evidence="9"Retinal reductase 1 shortName evidence="9"RalR1 alternativeName: Short chain dehydrogenase/reductase family 7C member 1
displayName
UniProt:Q8TC12 RDH11
geneName
-
RDH11
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ARSDR1
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PSDR1
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SDR7C1
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CGI-82
identifier
Q8TC12
isSequenceChanged
false
keyword
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Acetylation
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Alternative splicing
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Cataract
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Dwarfism
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Endoplasmic reticulum
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Lipid metabolism
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Membrane
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NADP
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Oxidoreductase
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Proteomics identification
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Reference proteome
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Signal-anchor
-
Transmembrane
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Transmembrane helix
moleculeType
Protein
otherIdentifier
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11743034_x_at
-
11748807_a_at
-
11758709_s_at
-
16794064
-
217775_PM_s_at
-
217775_s_at
-
217776_PM_at
-
217776_at
-
3569402
-
3569403
-
3569404
-
3569410
-
3569411
-
3569412
-
3569413
-
3569416
-
3569417
-
3569418
-
3569419
-
3569420
-
3569421
-
3569422
-
3569423
-
3569424
-
3569425
-
3569426
-
3569427
-
3569428
-
3569434
-
3569435
-
3569436
-
41172_at
-
48690_r_at
-
51109
-
61103_at
-
7979743
-
A_23_P25684
-
GE61090
-
GO:0001523
-
GO:0001917
-
GO:0004745
-
GO:0005515
-
GO:0005783
-
GO:0005789
-
GO:0006629
-
GO:0007601
-
GO:0016020
-
GO:0016491
-
GO:0016616
-
GO:0033721
-
GO:0042572
-
GO:0042574
-
GO:0050877
-
GO:0052650
-
GO:0098754
-
GO:0102354
-
GO:0110095
-
HMNXSV003019164
-
ILMN_1768719
-
ILMN_2128741
-
PH_hs_0023141
-
TC14002056.hg
-
TC14002328.hg
-
g7705790_3p_a_at
-
g9622123_3p_at
schemaClass
ReferenceGeneProduct
secondaryIdentifier
-
RDH11_HUMAN
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A6NDK3
-
A8K062
-
B2RB26
-
B4DDW0
-
Q0QD40
-
Q6IAH5
-
Q9NRW0
-
Q9Y391
sequenceLength
318
stId
uniprot:Q8TC12