UniProt:Q86X52 CHSY1

chain
  • chain:1-802
checksum 5B4C02670332FA0E
comment
  • FUNCTION Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.CATALYTIC ACTIVITY 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)CATALYTIC ACTIVITY 3-O-{beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-{[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP + H(+)CATALYTIC ACTIVITY 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)CATALYTIC ACTIVITY 3-O-{[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP + H(+)COFACTOR Divalent metal cations. Highest activities are measured with Co(2+), Mn(2+) and Cd(2+).SUBCELLULAR LOCATION Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the chondroitin N-acetylgalactosaminyltransferase family.SEQUENCE CAUTION Extended N-terminus.ONLINE INFORMATION Chondroitin sulfate synthase 1
created [InstanceEdit:217385] Schmidt, EE, 2008年03月27日 06:23:53
crossReference
databaseName UniProt
dbId 223471
description
  • recommendedName: fullName evidence="8"Chondroitin sulfate synthase 1 ecNumber evidence="4"2.4.1.175 ecNumber evidence="4"2.4.1.226 alternativeName: Chondroitin glucuronyltransferase 1 alternativeName: Chondroitin synthase 1 shortName: ChSy-1 alternativeName: Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1 alternativeName: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1 alternativeName: N-acetylgalactosaminyltransferase 1
displayName UniProt:Q86X52 CHSY1
geneName
  • CHSY1
  • CHSY
  • CSS1
  • KIAA0990
  • UNQ756/PRO1487
identifier Q86X52
isSequenceChanged false
keyword
  • Disease variant
  • Glycoprotein
  • Golgi apparatus
  • Membrane
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Signal-anchor
  • Transferase
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025年02月21日
moleculeType Protein
name
  • CHSY1
otherIdentifier
  • 11739359_a_at
  • 11746565_a_at
  • 11757950_s_at
  • 16813871
  • 203044_PM_at
  • 203044_at
  • 22856
  • 3642086
  • 3642087
  • 3642088
  • 3642089
  • 3642090
  • 3642106
  • 3642107
  • 3642108
  • 3642109
  • 3642111
  • 3642120
  • 3642121
  • 3642122
  • 3642123
  • 3642124
  • 3642125
  • 3642126
  • 3642128
  • 3642129
  • 3642134
  • 3642136
  • 41447_at
  • 7991581
  • A_23_P37484
  • GE53642
  • GO:0000139
  • GO:0002063
  • GO:0005576
  • GO:0005794
  • GO:0006790
  • GO:0008376
  • GO:0009954
  • GO:0016020
  • GO:0016740
  • GO:0016757
  • GO:0030279
  • GO:0031667
  • GO:0032580
  • GO:0045880
  • GO:0046872
  • GO:0047238
  • GO:0048856
  • GO:0050510
  • GO:0050650
  • GO:0051216
  • GO:0051923
  • GO:0060349
  • GO:1901135
  • HMNXSV003035135
  • ILMN_1791576
  • PH_hs_0029086
  • TC15002005.hg
  • g7662433_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CHSS1_HUMAN
  • Q6UX38
  • Q7LFU5
  • Q9Y2J5
sequenceLength 802
species [Species:48887] Homo sapiens
stId uniprot:Q86X52
url http://purl.uniprot.org/uniprot/Q86X52
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