FUNCTION Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.CATALYTIC ACTIVITY N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]COFACTOR Binds 1 zinc ion per subunit.PATHWAY Protein modification; protein glycosylation.SUBUNIT Homodimer; disulfide-linked.SUBCELLULAR LOCATION Glycosylated.SIMILARITY Belongs to the glycosyl hydrolase 38 family.
recommendedName: Alpha-mannosidase 2 ecNumber evidence="2"3.2.1.114 alternativeName: Golgi alpha-mannosidase II shortName: AMan II shortName: Man II alternativeName: Mannosidase alpha class 2A member 1 alternativeName: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase