FUNCTION Acts as a RAC1 guanine nucleotide exchange factor (GEF).SUBUNIT Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 (By similarity). Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2. Interacts with PARVG; the guanine nucleotide exchange factor activity of ARHGEF6 is essential for PARVG-induced enhancement of cell spreading (PubMed:16517730).INTERACTION Ubiquitous.