checksum
3019B2DCCC19A584
comment
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FUNCTION Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:16638743, PubMed:31932717, PubMed:8663203, PubMed:9295285). Has activity toward HIV envelope glycoprotein gp120, EA2, MUC2, MUC1A and MUC5AC (PubMed:8663203, PubMed:9295285). Probably glycosylates fibronectin in vivo (PubMed:9295285). Glycosylates FGF23 (PubMed:16638743, PubMed:31932717).CATALYTIC ACTIVITY L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)COFACTOR Protein modification; protein glycosylation.INTERACTION Resides preferentially in the trans and medial parts of the Golgi stack.ALTERNATIVE PRODUCTS Expressed in organs that contain secretory epithelial glands. Highly expressed in pancreas, skin, kidney and testis. Weakly expressed in prostate, ovary, intestine and colon. Also expressed in placenta and lung and fetal lung and fetal kidney.DOMAIN There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.DOMAIN The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity). Essential for glycosylation of FGF23 (PubMed:31932717).DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Overexpressed in many differentiated carcinomas, suggesting that it may serve as a marker of tumor differentiation.SIMILARITY Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION Polypeptide N-acetylgalactosaminyltransferase 3
databaseName
UniProt
dbId
148030
description
-
recommendedName: Polypeptide N-acetylgalactosaminyltransferase 3 ecNumber evidence="9 10 11 12"2.4.1.41 alternativeName: Polypeptide GalNAc transferase 3 shortName: GalNAc-T3 shortName: pp-GaNTase 3 alternativeName: Protein-UDP acetylgalactosaminyltransferase 3 alternativeName: UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3
displayName
UniProt:Q14435 GALNT3
identifier
Q14435
isSequenceChanged
false
keyword
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Alternative splicing
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Disease variant
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Disulfide bond
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Glycoprotein
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Glycosyltransferase
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Golgi apparatus
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Lectin
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Manganese
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Membrane
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Metal-binding
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Proteomics identification
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Reference proteome
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Signal-anchor
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Transferase
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Transmembrane
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Transmembrane helix
moleculeType
Protein
otherIdentifier
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11721353_at
-
11721354_at
-
11760826_at
-
16904551
-
16904573
-
203397_PM_s_at
-
203397_s_at
-
203398_PM_s_at
-
203398_s_at
-
2585139
-
2585140
-
2585141
-
2585142
-
2585143
-
2585144
-
2585146
-
2585147
-
2585148
-
2585149
-
2585150
-
2585151
-
2585154
-
2585156
-
2585157
-
2585158
-
2585160
-
2585170
-
2585171
-
2585172
-
2585182
-
2585183
-
2585184
-
2585185
-
2585186
-
2585187
-
2585188
-
2585189
-
2585205
-
2585207
-
2585209
-
2585211
-
2585213
-
2585215
-
2585221
-
2591
-
36483_at
-
36484_at
-
8056408
-
A_23_P209459
-
A_24_P114249
-
GE61786
-
GO:0000139
-
GO:0001958
-
GO:0002063
-
GO:0003824
-
GO:0004653
-
GO:0005509
-
GO:0005794
-
GO:0005975
-
GO:0005976
-
GO:0006486
-
GO:0006493
-
GO:0006915
-
GO:0007283
-
GO:0008543
-
GO:0010467
-
GO:0016020
-
GO:0016266
-
GO:0016740
-
GO:0016757
-
GO:0018242
-
GO:0018243
-
GO:0022414
-
GO:0030145
-
GO:0030246
-
GO:0032580
-
GO:0035264
-
GO:0046872
-
GO:0048469
-
GO:0048471
-
GO:0048856
-
GO:0050650
-
GO:0060173
-
GO:0070062
-
GO:0140096
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GO:1901135
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HMNXSV003005023
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HMNXSV003012231
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HMNXSV003036870
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Hs.278611.0.S1_3p_a_at
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ILMN_1671039
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PH_hs_0014292
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PH_hs_0032386
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TC02002492.hg
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X92689_at
-
p9388
schemaClass
ReferenceGeneProduct
secondaryIdentifier
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GALT3_HUMAN
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Q53TG9
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Q7Z476
sequenceLength
633
stId
uniprot:Q14435