FUNCTION Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation.ACTIVITY REGULATION KATP channels are regulated by cytoplasmic ATP/ADP ratios; ATP inhibits the channel by closing the pore, while ADP activates the channel (PubMed:29286281, PubMed:34815345). Activated by phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) (PubMed:34815345).SUBUNIT Forms an heterooctamer with KCNJ11; four ABCC8/SUR1 molecules interact with one KCNJ11 homotetramer.INTERACTION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Abundant isoform with prodiabetic properties, predominant in heart.SIMILARITY Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.ONLINE INFORMATION Database for mutations in ABC proteins