FUNCTION Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.FUNCTION Restin potently inhibits angiogenesis.SUBUNIT Trimer; disulfide-linked.SUBUNIT Interacts moderately with EFEMP2.SUBCELLULAR LOCATION Detected in fibroblasts and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected in placenta (at protein level) (PubMed:32337544). Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney.PTM Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.PTM O-glycosylated; with core 1 or possibly core 8 glycans. Contains chondroitin sulfate.SIMILARITY Belongs to the multiplexin collagen family.CAUTION The name restin has also been used for CAP-Gly domain-containing linker protein 1 the product of the CLIP1 gene.