UniProt:P18502 ptc

chain
  • chain:1-1286
checksum 5F22A956F8BE0EC6
comment
  • FUNCTION Segmentation polarity protein. Acts as a receptor for the hedgehog protein (hh). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).SUBUNIT Interacts (via C-terminal cytoplasmic region) with CG5504/l(2)tid; the interaction is probably direct (PubMed:12783860). Interacts with hh/hedgehog (PubMed:12783860).SUBCELLULAR LOCATION Embryonic lethal with epidermal pattern formation defects.SIMILARITY Belongs to the patched family.
databaseName UniProt
dbId 97796
description
  • recommendedName: fullName evidence="6"Protein patched alternativeName: fullName evidence="5"Hedgehog receptor ptc
displayName UniProt:P18502 ptc
geneName
  • ptc
  • CG2411
identifier P18502
isSequenceChanged false
keyword
  • Developmental protein
  • Glycoprotein
  • Membrane
  • Receptor
  • Reference proteome
  • Segmentation polarity protein
  • Transmembrane
  • Transmembrane helix
moleculeType Protein
name
  • ptc
otherIdentifier
  • 143395_at
  • 1639749_a_at
  • 35851
  • GO:0001746
  • GO:0005119
  • GO:0005515
  • GO:0005886
  • GO:0005929
  • GO:0007346
  • GO:0007367
  • GO:0007411
  • GO:0007455
  • GO:0007476
  • GO:0008158
  • GO:0008406
  • GO:0009925
  • GO:0016020
  • GO:0016192
  • GO:0030139
  • GO:0030228
  • GO:0030707
  • GO:0031410
  • GO:0035225
  • GO:0035332
  • GO:0038024
  • GO:0042981
  • GO:0043226
  • GO:0045169
  • GO:0045879
  • GO:0048099
  • GO:0048100
  • GO:0048856
  • GO:0055088
  • GO:0070273
  • GO:0070300
  • GO:0097108
  • GO:2000274
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PTC_DROME
  • Q9V4W3
sequenceLength 1286
stId uniprot:P18502
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