chain
-
initiator methionine:1
-
chain:2-363
checksum
786BC5085CA9AFCB
comment
-
FUNCTION Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:16670267, PubMed:23193172, PubMed:26166670, PubMed:8452534, PubMed:9361033). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (PubMed:26038697).CATALYTIC ACTIVITY adenosine + H2O + H(+) = inosine + NH4(+)CATALYTIC ACTIVITY 2'-deoxyadenosine + H2O + H(+) = 2'-deoxyinosine + NH4(+)CATALYTIC ACTIVITY cordycepin + H2O + H(+) = 3'-deoxyinosine + NH4(+)COFACTOR Binds 1 zinc ion per subunit.ACTIVITY REGULATION Inhibited by Cu(2+) and Hg(2+), coformycin, deoxycoformycin (dCF), 2-deoxyadenosine, 6-methylaminopurine riboside, 2-3-iso-propylidene-adenosine, pentostatin, naringin and erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA).BIOPHYSICOCHEMICAL PROPERTIES Interacts with DPP4 (via extracellular domain) (PubMed:10951221, PubMed:14691230, PubMed:15016824, PubMed:7907293, PubMed:8101391). Interacts with PLG (via Kringle 4 domain); the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824).INTERACTION Colocalized with DPP4 at the cell surface.TISSUE SPECIFICITY Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues.INDUCTION Up-regulated by hypoxia.POLYMORPHISM There is a common allele, ADA*2, also known as the ADA 2 allozyme. It is associated with the reduced metabolism of adenosine to inosine. It specifically enhances deep sleep and slow-wave activity (SWA) during sleep.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.SEQUENCE CAUTION Leiden Open Variation Database (LOVD)ONLINE INFORMATION Adenosine deaminase entry
databaseName
UniProt
dbId
49702
description
-
recommendedName: Adenosine deaminase ecNumber evidence="11 17 19 30 33"3.5.4.4 alternativeName: Adenosine aminohydrolase
displayName
UniProt:P00813 ADA
identifier
P00813
isSequenceChanged
false
keyword
-
3D-structure
-
Acetylation
-
Cell adhesion
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Cell junction
-
Cell membrane
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Cytoplasm
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Cytoplasmic vesicle
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Direct protein sequencing
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Disease variant
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Hereditary hemolytic anemia
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Hydrolase
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Lysosome
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Membrane
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Metal-binding
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Nucleotide metabolism
-
Proteomics identification
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Reference proteome
-
SCID
-
Zinc
moleculeType
Protein
schemaClass
ReferenceGeneProduct
sequenceLength
363
stId
uniprot:P00813