checksum
DCB7F5A1C3FF7689
comment
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FUNCTION Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity).CATALYTIC ACTIVITY all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholineCATALYTIC ACTIVITY 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholineCATALYTIC ACTIVITY 1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = all-trans-retinyl heptanoate + 2-heptanoyl-sn-glycero-3-phosphocholine + apo--[retinol-binding protein]CATALYTIC ACTIVITY 1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]CATALYTIC ACTIVITY all-trans-retinol--[retinol-binding protein] + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholineCATALYTIC ACTIVITY 1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]ACTIVITY REGULATION Inhibited by all-trans-retinyl alpha-bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK).PATHWAY Cofactor metabolism; retinol metabolism.INTERACTION Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity).TISSUE SPECIFICITY Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain.INDUCTION LRAT activity is up-regulated by dietary vitamin A. Under conditions of vitamin A depletion, LRAT expression in the liver is induced by retinoic acid (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the H-rev107 family.
databaseName
UniProt
dbId
74826
description
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recommendedName: fullName evidence="11"Lecithin retinol acyltransferase ecNumber evidence="12"2.3.1.135 alternativeName: Phosphatidylcholine--retinol O-acyltransferase
displayName
UniProt:O95237 LRAT
identifier
O95237
isSequenceChanged
false
keyword
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Acyltransferase
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Cytoplasm
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Disease variant
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Endoplasmic reticulum
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Endosome
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Leber congenital amaurosis
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Lipid metabolism
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Membrane
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Proteomics identification
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Reference proteome
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Sensory transduction
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Transferase
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Transmembrane
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Transmembrane helix
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Vision
moleculeType
Protein
otherIdentifier
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11738044_a_at
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11738045_a_at
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11738046_a_at
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220317_PM_at
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220317_at
-
2748590
-
2748591
-
2748596
-
2748602
-
2748603
-
2748604
-
2748607
-
2748613
-
2748618
-
2748627
-
2748628
-
2748629
-
2748630
-
2748631
-
2748632
-
2748633
-
2748636
-
2748637
-
2748638
-
2748639
-
2748640
-
2748641
-
2748642
-
2748643
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8097920
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9227
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A_14_P100245
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A_23_P167182
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A_24_P260325
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A_32_P113066
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GO:0001523
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GO:0001972
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GO:0005515
-
GO:0005737
-
GO:0005768
-
GO:0005771
-
GO:0005783
-
GO:0005789
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GO:0005791
-
GO:0006629
-
GO:0006766
-
GO:0006776
-
GO:0007601
-
GO:0008289
-
GO:0008374
-
GO:0009617
-
GO:0016020
-
GO:0016416
-
GO:0016740
-
GO:0016746
-
GO:0019841
-
GO:0019915
-
GO:0032370
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GO:0032526
-
GO:0033189
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GO:0042572
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GO:0047173
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GO:0048471
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GO:0050877
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GO:1990830
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HMNXSV003000746
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ILMN_1673491
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PH_hs_0022650
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TC04002280.hg
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g4758683_3p_at
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p26271
schemaClass
ReferenceGeneProduct
sequenceLength
230
stId
uniprot:O95237