UniProt:O00401 WASL

chain
  • initiator methionine:1
  • chain:2-505
checksum B5895C6055E23049
comment
  • FUNCTION Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742).SUBUNIT Binds actin and the Arp2/3 complex (PubMed:22847007). Interacts with CDC42 (PubMed:9422512). Interacts with FCHSD1 (By similarity). Interacts with FCHSD2 (PubMed:29887380). Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP (PubMed:17015620, PubMed:19767742, PubMed:24332715). Interacts with SNX9 (By similarity). Interacts with the WW domains of PRPF40A/FBP11 (By similarity). Interacts with PTK2/FAK1 (By similarity). Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with NOSTRIN (PubMed:16234328). Binds to TNK2 (PubMed:16257963). Interacts with SNX33 (PubMed:19487689). Interacts with NONO (via second RRM domain); the interaction is direct (PubMed:16767080). Component of a multiprotein complex with NONO and SFPQ; associates with the complex via direct interaction with NONO (PubMed:16767080).SUBUNIT (Microbial infection) Interacts with E.coli effector protein EspF(U) (PubMed:19366662, PubMed:22921828). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U) (PubMed:22921828).SUBUNIT (Microbial infection) Interacts with Shigella flexneri protein IcsA (PubMed:10491394, PubMed:9582270). The interaction with IcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly (PubMed:10491394, PubMed:9582270).INTERACTION Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (By similarity).PTM Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity.
crossReference
databaseName UniProt
dbId 67296
description
  • recommendedName: fullName evidence="22"Actin nucleation-promoting factor WASL alternativeName: fullName evidence="21"Neural Wiskott-Aldrich syndrome protein shortName evidence="21"N-WASP
displayName UniProt:O00401 WASL
geneName
  • WASL
identifier O00401
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Actin-binding
  • Cell cycle
  • Cell division
  • Cytoplasm
  • Cytoskeleton
  • Methylation
  • Mitosis
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9963647] Weiser, Joel, 2025年08月15日
moleculeType Protein
name
  • WASL
otherIdentifier
  • 11717284_a_at
  • 11717285_a_at
  • 11754385_s_at
  • 17062460
  • 205809_PM_s_at
  • 205809_s_at
  • 205810_PM_s_at
  • 205810_s_at
  • 224813_PM_at
  • 224813_at
  • 3070714
  • 3070715
  • 3070716
  • 3070717
  • 3070721
  • 3070722
  • 3070727
  • 3070728
  • 3070729
  • 3070730
  • 3070731
  • 3070732
  • 3070735
  • 3070736
  • 3070737
  • 3070750
  • 3070751
  • 3070752
  • 3070753
  • 3070754
  • 3070755
  • 3070756
  • 321_at
  • 39875_at
  • 44736_at
  • 8142671
  • 8976
  • A_33_P3405444
  • D88460_at
  • GE57430
  • GO:0003779
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005789
  • GO:0005829
  • GO:0005856
  • GO:0005886
  • GO:0006355
  • GO:0006900
  • GO:0007015
  • GO:0008092
  • GO:0008154
  • GO:0009617
  • GO:0015629
  • GO:0016050
  • GO:0030027
  • GO:0030036
  • GO:0030041
  • GO:0030050
  • GO:0030478
  • GO:0030666
  • GO:0030695
  • GO:0031267
  • GO:0031410
  • GO:0031503
  • GO:0032880
  • GO:0035023
  • GO:0045944
  • GO:0051301
  • GO:0051491
  • GO:0051653
  • GO:0060997
  • GO:0061024
  • GO:0065003
  • GO:0070062
  • GO:0098978
  • GO:0099175
  • GO:1903526
  • GO:2000370
  • GO:2000402
  • HMNXSV003030896
  • Hs.170065.0.S1_3p_at
  • Hs.288830.0.A1_3p_a_at
  • ILMN_1666004
  • TC07001823.hg
  • g4505322_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • WASL_HUMAN
  • A1JUI9
  • Q7Z746
sequenceLength 505
species [Species:48887] Homo sapiens
stId uniprot:O00401
url http://purl.uniprot.org/uniprot/O00401

Referrals

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