Reactome Pathway Database

Schema > Reaction > Entries

Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 Show undefined attributes

catalystActivity

[CatalystActivity:10628885] mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1A1/A2/C1 [Golgi membrane]

category transition

compartment

created [InstanceEdit:10603480] Weiser, Joel, 2025年08月27日

dbId 10628905

displayName Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2

eventOf

[Pathway:R-XTR-964827] Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 - Xenopus tropicalis

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-XTR-964768] Addition of GlcNAc to the glycan on the A arm - Xenopus tropicalis

inferredFrom

[Reaction:R-HSA-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 - Homo sapiens

input

[DefinedSet:R-ALL-964831] (GlcNAc)2 (Man)8 glycans [Golgi lumen]

isInDisease false

isInferred true

maxDepth 1

name

Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:205621] Xenopus tropicalis

stId R-XTR-964825

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-XTR-964827] Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2

(precedingEvent)

[Reaction:R-XTR-964768] Addition of GlcNAc to the glycan on the A arm

(inferredTo)

[Reaction:R-HSA-964825] Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2

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