Reactome Pathway Database

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ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A Show undefined attributes

catalystActivity

[CatalystActivity:10625000] palmitoyl-CoA ligase activity of ACSL3,4 [mitochondrial outer membrane]

category transition

compartment

[Compartment:17906] mitochondrial outer membrane

created [InstanceEdit:10603480] Weiser, Joel, 2025年08月27日

dbId 10625002

displayName ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A

eventOf

[Pathway:R-XTR-434313] Intracellular metabolism of fatty acids regulates insulin secretion - Xenopus tropicalis

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-XTR-9911362] CPT1B transfers PALM to CAR - Xenopus tropicalis

inferredFrom

[Reaction:R-HSA-434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A
a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate

output

precedingEvent

[Reaction:R-XTR-434381] CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol - Xenopus tropicalis

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:205621] Xenopus tropicalis

stId R-XTR-434382

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-XTR-434313] Intracellular metabolism of fatty acids regulates insulin secretion

(precedingEvent)

[Reaction:R-XTR-9911362] CPT1B transfers PALM to CAR

(inferredTo)

[Reaction:R-HSA-434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A

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