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CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL Show undefined attributes

catalystActivity

[CatalystActivity:10615145] sterol 12-alpha-hydroxylase activity of CYP8B1 [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:10603480] Weiser, Joel, 2025年08月27日

dbId 10615414

displayName CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL

eventOf

[Pathway:R-XTR-211994] Sterols are 12-hydroxylated by CYP8B1 - Xenopus tropicalis
[Pathway:R-XTR-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Xenopus tropicalis

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-XTR-193755] 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one - Xenopus tropicalis

inferredFrom

[Reaction:R-HSA-193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL
4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one
4-Cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ + O2 => 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one + NADP+ + H2O

output

precedingEvent

[Reaction:R-XTR-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Xenopus tropicalis

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:205621] Xenopus tropicalis

stId R-XTR-193709

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(precedingEvent)

[Reaction:R-XTR-193755] 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one

(inferredTo)

[Reaction:R-HSA-193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL

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