Reactome Pathway Database

Schema > Reaction > Entries

PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter Show undefined attributes

catalystActivity

[CatalystActivity:10531898] histone H3K27 methyltransferase activity of PRC2 (EZH2) Core:Nucleosome:CDH1 gene [nucleoplasm]

category transition

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10531900

displayName PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter

eventOf

[Pathway:R-SSC-9764725] Negative Regulation of CDH1 Gene Transcription - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-9764932] PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-9764932

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-9764725] Negative Regulation of CDH1 Gene Transcription

(inferredTo)

[Reaction:R-HSA-9764932] PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter

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