Reactome Pathway Database

Schema > Reaction > Entries

Raf dimer inhibitors bind RAF heterodimers Show undefined attributes

category binding

compartment

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10528791

displayName Raf dimer inhibitors bind RAF heterodimers

eventOf

[Pathway:R-SSC-5673000] RAF activation - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Raf dimer inhibitors bind RAF heterodimers

output

[Complex:R-SSC-9653109] p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane]

precedingEvent

[Reaction:R-SSC-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Sus scrofa

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-9653108

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-5673000] RAF activation

(inferredTo)

[Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers

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