Reactome Pathway Database

Schema > Reaction > Entries

ME2 tetramer decarboxylates MAL to PYR Show undefined attributes

catalystActivity

[CatalystActivity:10525391] malate dehydrogenase (decarboxylating) (NAD+) activity of ME2:Mg2+ tetramer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10525393

displayName ME2 tetramer decarboxylates MAL to PYR

eventOf

[Pathway:R-SSC-70268] Pyruvate metabolism - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

inferredFrom

[Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

ME2 tetramer decarboxylates MAL to PYR
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR

output

precedingEvent

[Reaction:R-SSC-70982] FH tetramer hydrates fumarate to L-malate - Sus scrofa

regulatedBy

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-9012268

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-70268] Pyruvate metabolism

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR

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